FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019820906> ?p ?o ?g. }

• W2019820906 endingPage "e37553" @default.
• W2019820906 startingPage "e37553" @default.
• W2019820906 abstract "Between 1996 and 2006, the US Centers for Disease Control reported that the only category of food-borne infections increasing in frequency were those caused by members of the genus Vibrio. The Gram-negative bacterium Vibrio vulnificus is a ubiquitous inhabitant of estuarine waters, and is the number one cause of seafood-related deaths in the US. Many V. vulnificus isolates have been studied, and it has been shown that two genetically distinct subtypes, distinguished by 16S rDNA and other gene polymorphisms, are associated predominantly with either environmental or clinical isolation. While local genetic differences between the subtypes have been probed, only the genomes of clinical isolates have so far been completely sequenced. In order to better understand V. vulnificus as an agent of disease and to identify the molecular components of its virulence mechanisms, we have completed whole genome shotgun sequencing of three diverse environmental genotypes using a pyrosequencing approach. V. vulnificus strain JY1305 was sequenced to a depth of 33×, and strains E64MW and JY1701 were sequenced to lesser depth, covering approximately 99.9% of each genome. We have performed a comparative analysis of these sequences against the previously published sequences of three V. vulnificus clinical isolates. We find that the genome of V. vulnificus is dynamic, with 1.27% of genes in the C-genotype genomes not found in the E- genotype genomes. We identified key genes that differentiate between the genomes of the clinical and environmental genotypes. 167 genes were found to be specifically associated with environmental genotypes and 278 genes with clinical genotypes. Genes specific to the clinical strains include components of sialic acid catabolism, mannitol fermentation, and a component of a Type IV secretory pathway VirB4, as well as several other genes with potential significance for human virulence. Genes specific to environmental strains included several that may have implications for the balance between self-preservation under stress and nutritional competence." @default.
• W2019820906 created "2016-06-24" @default.
• W2019820906 creator A5002835725 @default.
• W2019820906 creator A5014931299 @default.
• W2019820906 creator A5029254424 @default.
• W2019820906 creator A5049029368 @default.
• W2019820906 creator A5054883594 @default.
• W2019820906 creator A5055959902 @default.
• W2019820906 creator A5058868438 @default.
• W2019820906 creator A5081210319 @default.
• W2019820906 creator A5082664710 @default.
• W2019820906 creator A5082676132 @default.
• W2019820906 date "2012-05-25" @default.
• W2019820906 modified "2023-10-10" @default.
• W2019820906 title "Pyrosequencing-Based Comparative Genome Analysis of Vibrio vulnificus Environmental Isolates" @default.
• W2019820906 cites W1527927437 @default.
• W2019820906 cites W1643659384 @default.
• W2019820906 cites W1973320011 @default.
• W2019820906 cites W1977419494 @default.
• W2019820906 cites W1980561232 @default.
• W2019820906 cites W1986296689 @default.
• W2019820906 cites W2003828458 @default.
• W2019820906 cites W2004559916 @default.
• W2019820906 cites W2008001220 @default.
• W2019820906 cites W2008821578 @default.
• W2019820906 cites W2008856488 @default.
• W2019820906 cites W2013943315 @default.
• W2019820906 cites W2014546802 @default.
• W2019820906 cites W2021357964 @default.
• W2019820906 cites W2023063949 @default.
• W2019820906 cites W2032870665 @default.
• W2019820906 cites W2040262433 @default.
• W2019820906 cites W2040641257 @default.
• W2019820906 cites W2041257508 @default.
• W2019820906 cites W2045843097 @default.
• W2019820906 cites W2048759471 @default.
• W2019820906 cites W2048875442 @default.
• W2019820906 cites W2049733502 @default.
• W2019820906 cites W2052036592 @default.
• W2019820906 cites W2054799851 @default.
• W2019820906 cites W2060987350 @default.
• W2019820906 cites W2067402200 @default.
• W2019820906 cites W2070389200 @default.
• W2019820906 cites W2072302993 @default.
• W2019820906 cites W2073184838 @default.
• W2019820906 cites W2073245935 @default.
• W2019820906 cites W2076556358 @default.
• W2019820906 cites W2078774003 @default.
• W2019820906 cites W2089594628 @default.
• W2019820906 cites W2096803923 @default.
• W2019820906 cites W2100303227 @default.
• W2019820906 cites W2103017472 @default.
• W2019820906 cites W2103546861 @default.
• W2019820906 cites W2104840825 @default.
• W2019820906 cites W2106882534 @default.
• W2019820906 cites W2107282968 @default.
• W2019820906 cites W2112463359 @default.
• W2019820906 cites W2114377304 @default.
• W2019820906 cites W2115102447 @default.
• W2019820906 cites W2115860061 @default.
• W2019820906 cites W2119582961 @default.
• W2019820906 cites W2127697119 @default.
• W2019820906 cites W2128114769 @default.
• W2019820906 cites W2129232972 @default.
• W2019820906 cites W2129821327 @default.
• W2019820906 cites W2130181888 @default.
• W2019820906 cites W2135771899 @default.
• W2019820906 cites W2138201809 @default.
• W2019820906 cites W2139684486 @default.
• W2019820906 cites W2142916754 @default.
• W2019820906 cites W2148472871 @default.
• W2019820906 cites W2150775872 @default.
• W2019820906 cites W2156028799 @default.
• W2019820906 cites W2156745374 @default.
• W2019820906 cites W2157748357 @default.
• W2019820906 cites W2159929906 @default.
• W2019820906 cites W2160053034 @default.
• W2019820906 cites W2163799598 @default.
• W2019820906 cites W2164974246 @default.
• W2019820906 cites W2166406784 @default.
• W2019820906 cites W2167976954 @default.
• W2019820906 cites W2168470451 @default.
• W2019820906 cites W2169883440 @default.
• W2019820906 cites W2171511200 @default.
• W2019820906 cites W4250052351 @default.
• W2019820906 doi "https://doi.org/10.1371/journal.pone.0037553" @default.
• W2019820906 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3360785" @default.
• W2019820906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22662170" @default.
• W2019820906 hasPublicationYear "2012" @default.
• W2019820906 type Work @default.
• W2019820906 sameAs 2019820906 @default.
• W2019820906 citedByCount "66" @default.
• W2019820906 countsByYear W20198209062012 @default.
• W2019820906 countsByYear W20198209062013 @default.
• W2019820906 countsByYear W20198209062014 @default.
• W2019820906 countsByYear W20198209062015 @default.
• W2019820906 countsByYear W20198209062016 @default.
• W2019820906 countsByYear W20198209062017 @default.

• next