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- W2019821859 abstract "The identified dopamine cell of Planorbis corneus is described as a model system to study neurotransmitter storage and dynamics. Techniques developed with this model system include capillary electrophoresis with electrochemical detection and microelectrochemistry at single cells. These techniques provide a powerful combination to examine single cell neurochemistry. Whole cell and cytoplasmic dopamine concentrations have been quantified with capillary electrophoresis. Additionally, this technique has been used to profile amino acids and to quantify two compartments of neurotransmitter in a single cell. Individual exocytosis events have been monitored at the cell body of the dopamine cell of P. corneus with microelectrodes. In this case, two different types of vesicles have been identified based on the amount of transmitter released. The psychostimulant, amphetamine, has been shown to selectively affect the amount of dopamine in these vesicles with lower to higher doses affecting the larger to smaller vesicle types, respectively. Microelectrochemistry at single nerve cells has also been used to demonstrate reverse transport of dopamine across the cell membrane and to suggest a role of this process in the molecular mechanism of amphetamine." @default.
- W2019821859 created "2016-06-24" @default.
- W2019821859 creator A5046460191 @default.
- W2019821859 creator A5055964392 @default.
- W2019821859 date "1999-02-01" @default.
- W2019821859 modified "2023-10-03" @default.
- W2019821859 title "Chemical profiles and monitoring dynamics at an individual nerve cell in Planorbis corneus with electrochemical detection" @default.
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- W2019821859 doi "https://doi.org/10.1016/s0731-7085(98)00088-0" @default.
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