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• W2019834042 abstract "Auto-antibodies can exist in small amounts in normal organisms and appear in quantity after tissue destruction or alteration by exogeneous agents. Assuming that the immunological phenomena originally are not a “defence mechanism” but rather a physiological system of handling metabolic and catabolic substances, the appearance of auto-Ab is a normal process. “Self” constituents are normally degraded by autolytic enzymes, but in cases of massive destruction of tissues, these enzymes can be inhibited by substrate excess. Cells capable of synthetizing auto-Abs which exist normally are then activated and auto-Abs appear; they facilitate phagocytosis. The same mechanism acts for “not self” substances if undegraded by existing enzymes. Tolerogens, resulting from degradation, can block the receptors on immunocompetent cells. Possibly, they may differ from immunogens in possessing only one determinant group susceptible to do it. Experimental data are cited supporting the “transporteurs” theory proposed years ago by the author." @default.
• W2019834042 created "2016-06-24" @default.
• W2019834042 creator A5070864023 @default.
• W2019834042 date "1975-11-01" @default.
• W2019834042 modified "2023-09-24" @default.
• W2019834042 title "Hypothesis. Auto-antibodies and immunological theories: An analytical review" @default.
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• W2019834042 doi "https://doi.org/10.1016/0090-1229(75)90087-2" @default.
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