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- W201983721 abstract "ABSTRACT This paper summarizes our studies on phorbol ester (TPA)-induced, differentiation-associated changes in B-CLL cells. The TPA-CLL system is proposed as a suitable monoclonal model for B lymphocyte differentiation. Apart from TPA, also anti-IgM (F(ab)-fragment) as well as T/B-cell growth-promoting factor-containing supernatants of different cell lines could induce Ig secretion in CLL cells. Ig secretion was dependent on accessory T cells and monocytes. Two differentiation-associated parameters of TPA-induced CLL cells, namely cytoplasmic IgM and an altered (increased) sensitivity to lysis by natural killer (NK) cells, were positively correlated with the clinical activity of the leukemia." @default.
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- W201983721 date "1982-01-01" @default.
- W201983721 modified "2023-09-26" @default.
- W201983721 title "PHORBOL ESTER- AND ANTI-IgM-INDUCED DIFFERENTIATION OF HUMAN NEOPLASTIC B LYMPHOCYTES: MODULATION OF Ig SECRETION BY ACCESSORY CELLS AND CHANGES IN THE NK CELL SENSITIVITY OF TUMOR CELLS 11This work was supported by grants from the Swedish Cancer Society, NIH (R01-26752-03) and DFG Ka502-2/l." @default.
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- W201983721 doi "https://doi.org/10.1016/b978-0-12-722380-3.50056-8" @default.
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