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- W2019847538 abstract "Ticlopidine is an antiplatelet agent used in the prophylaxis of peripheral and cerebrovascular diseases, [1-3] ischemic heart disease, [1,3] and vascular complications of diabetes mellitus. [4] In healthy volunteers ticlopidine reduces the clearance of theophylline [5] and antipyrine, [6] probably by inhibiting the activity of cytochrome P450 enzymes. On the basis of these observations, the package insert in some countries contains a warning advising caution when ticlopidine is introduced in patients receiving therapy with highly metabolized drugs.We report a case of metabolic phenytoin-ticlopidine interaction in which phenytoin plasma concentrations increased and CNS toxicity appeared when ticlopidine was added to the therapeutic regimen.A 65-year-old man had a history of complex partial seizures, sometimes with secondary generalization, which started at the age of 52 years. A brain CT scan obtained at this time was normal. He had been treated with different antiepileptic regimens for about 10 …" @default.
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- W2019847538 date "1996-04-01" @default.
- W2019847538 modified "2023-09-25" @default.
- W2019847538 title "Ticlopidine impairs phenytoin clearance: A case report" @default.
- W2019847538 cites W2109713522 @default.
- W2019847538 doi "https://doi.org/10.1212/wnl.46.4.1172" @default.
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