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- W2019875332 abstract "Complexes of the type trans-[PdX2(isn)2] {X = Cl (1), N3 (2), SCN (3), NCO (4); isn = isonicotinamide} were synthesized and evaluated for in vitro antimycobacterial and antitumor activities. The coordination mode of the isonicotinamide and the pseudohalide ligands was inferred by IR spectroscopy. Single crystal X-ray diffraction determination on 2 showed that coordination geometry around Pd(II) is nearly square planar, with the ligands in a trans configuration. All the compounds demonstrated better in vitro activity against Mycobacterium tuberculosis than isonicotinamide and pyrazinamide. Among the complexes, compound 2 was found to be the most active with MIC of 35.89 μM. Complexes 1–4 were also screened for their in vitro antitumor activity towards LM3 and LP07 murine cancer cell lines." @default.
- W2019875332 created "2016-06-24" @default.
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- W2019875332 date "2010-11-01" @default.
- W2019875332 modified "2023-10-01" @default.
- W2019875332 title "Antimycobacterial and antitumor activities of Palladium(II) complexes containing isonicotinamide (isn): X-ray structure of trans-[Pd(N3)2(isn)2]" @default.
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- W2019875332 doi "https://doi.org/10.1016/j.ejmech.2010.07.057" @default.
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