FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019879265> ?p ?o ?g. }

• W2019879265 endingPage "5885" @default.
• W2019879265 startingPage "5880" @default.
• W2019879265 abstract "Illumination of vertebrate rod photoreceptors leads to a decrease in the cytoplasmic cGMP concentration and closure of cyclic nucleotide-gated (CNG) channels. Except for Ca 2+ , which plays a negative feedback role in adaptation, and 11- cis -retinal, supplied by the retinal pigment epithelium, all of the biochemical machinery of phototransduction is thought to be contained within rod outer segments without involvement of extrinsic regulatory molecules. Here we show that insulin-like growth factor-I (IGF-I), a paracrine factor released from the retinal pigment epithelium, alters phototransduction by rapidly increasing the cGMP sensitivity of CNG channels. The IGF-I-signaling pathway ultimately involves a protein tyrosine phosphatase that catalyzes dephosphorylation of a specific residue in the α-subunit of the rod CNG channel protein. IGF-I conjointly accelerates the kinetics and increases the amplitude of the light response, distinct from events that accompany adaptation. These effects of IGF-I could result from the enhancement of the cGMP sensitivity of CNG channels. Hence, in addition to long-term control of development and survival of rods, growth factors regulate phototransduction in the short term by modulating CNG channels." @default.
• W2019879265 created "2016-06-24" @default.
• W2019879265 creator A5011895076 @default.
• W2019879265 creator A5034562989 @default.
• W2019879265 creator A5062569953 @default.
• W2019879265 creator A5084612504 @default.
• W2019879265 date "2001-04-24" @default.
• W2019879265 modified "2023-09-23" @default.
• W2019879265 title "Growth factors regulate phototransduction in retinal rods by modulating cyclic nucleotide-gated channels through dephosphorylation of a specific tyrosine residue" @default.
• W2019879265 cites W118255430 @default.
• W2019879265 cites W1496131947 @default.
• W2019879265 cites W1527371412 @default.
• W2019879265 cites W1534439131 @default.
• W2019879265 cites W1551182340 @default.
• W2019879265 cites W1584140846 @default.
• W2019879265 cites W1625740378 @default.
• W2019879265 cites W1653522334 @default.
• W2019879265 cites W1671361404 @default.
• W2019879265 cites W1845593512 @default.
• W2019879265 cites W192576757 @default.
• W2019879265 cites W1966631841 @default.
• W2019879265 cites W1973875627 @default.
• W2019879265 cites W1980862726 @default.
• W2019879265 cites W1985348163 @default.
• W2019879265 cites W1988404481 @default.
• W2019879265 cites W2004064874 @default.
• W2019879265 cites W2013257092 @default.
• W2019879265 cites W2029711851 @default.
• W2019879265 cites W2029804359 @default.
• W2019879265 cites W2030943487 @default.
• W2019879265 cites W2033434600 @default.
• W2019879265 cites W2034176125 @default.
• W2019879265 cites W2042162796 @default.
• W2019879265 cites W2042338200 @default.
• W2019879265 cites W2043433874 @default.
• W2019879265 cites W2047213268 @default.
• W2019879265 cites W2048419229 @default.
• W2019879265 cites W2067130567 @default.
• W2019879265 cites W2067649440 @default.
• W2019879265 cites W2069002173 @default.
• W2019879265 cites W2073513922 @default.
• W2019879265 cites W2082709236 @default.
• W2019879265 cites W2084479454 @default.
• W2019879265 cites W2106781808 @default.
• W2019879265 cites W2116873052 @default.
• W2019879265 cites W2145194565 @default.
• W2019879265 cites W2148130495 @default.
• W2019879265 cites W2176431604 @default.
• W2019879265 doi "https://doi.org/10.1073/pnas.101524998" @default.
• W2019879265 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/33307" @default.
• W2019879265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11320223" @default.
• W2019879265 hasPublicationYear "2001" @default.
• W2019879265 type Work @default.
• W2019879265 sameAs 2019879265 @default.
• W2019879265 citedByCount "37" @default.
• W2019879265 countsByYear W20198792652012 @default.
• W2019879265 countsByYear W20198792652014 @default.
• W2019879265 countsByYear W20198792652015 @default.
• W2019879265 countsByYear W20198792652016 @default.
• W2019879265 countsByYear W20198792652018 @default.
• W2019879265 countsByYear W20198792652020 @default.
• W2019879265 countsByYear W20198792652021 @default.
• W2019879265 countsByYear W20198792652023 @default.
• W2019879265 crossrefType "journal-article" @default.
• W2019879265 hasAuthorship W2019879265A5011895076 @default.
• W2019879265 hasAuthorship W2019879265A5034562989 @default.
• W2019879265 hasAuthorship W2019879265A5062569953 @default.
• W2019879265 hasAuthorship W2019879265A5084612504 @default.
• W2019879265 hasBestOaLocation W20198792652 @default.
• W2019879265 hasConcept C104317684 @default.
• W2019879265 hasConcept C11960822 @default.
• W2019879265 hasConcept C12554922 @default.
• W2019879265 hasConcept C131667965 @default.
• W2019879265 hasConcept C131829789 @default.
• W2019879265 hasConcept C149574991 @default.
• W2019879265 hasConcept C178666793 @default.
• W2019879265 hasConcept C181912034 @default.
• W2019879265 hasConcept C2778024200 @default.
• W2019879265 hasConcept C2778524494 @default.
• W2019879265 hasConcept C2778597717 @default.
• W2019879265 hasConcept C2780827179 @default.
• W2019879265 hasConcept C512185932 @default.
• W2019879265 hasConcept C55493867 @default.
• W2019879265 hasConcept C62478195 @default.
• W2019879265 hasConcept C80631254 @default.
• W2019879265 hasConcept C86803240 @default.
• W2019879265 hasConcept C95444343 @default.
• W2019879265 hasConceptScore W2019879265C104317684 @default.
• W2019879265 hasConceptScore W2019879265C11960822 @default.
• W2019879265 hasConceptScore W2019879265C12554922 @default.
• W2019879265 hasConceptScore W2019879265C131667965 @default.
• W2019879265 hasConceptScore W2019879265C131829789 @default.
• W2019879265 hasConceptScore W2019879265C149574991 @default.
• W2019879265 hasConceptScore W2019879265C178666793 @default.
• W2019879265 hasConceptScore W2019879265C181912034 @default.
• W2019879265 hasConceptScore W2019879265C2778024200 @default.
• W2019879265 hasConceptScore W2019879265C2778524494 @default.
• W2019879265 hasConceptScore W2019879265C2778597717 @default.

• next