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- W2019884119 abstract "ABSTRACT Alpha/beta interferons (IFN-α/β) are key mediators of innate immunity and important modulators of adaptive immunity. The mechanisms by which IFN-α/β are induced are becoming increasingly well understood. Recent studies showed that Toll-like receptors 7 and 8 expressed by plasmacytoid dendritic cells (pDCs) mediate the endosomal recognition of incoming viral RNA genomes, a process which requires myeloid differentiation factor 88 (MyD88). Here we investigate the requirements for virus-induced IFN-α/β production in cultures of bone marrow-derived murine myeloid DCs (mDCs). Using recombinant Semliki Forest virus blocked at different steps in the viral life cycle, we show that replication-defective virus induced IFN-α/β in mDCs while fusion-defective virus did not induce IFN-α/β. The response to replication-defective virus was largely intact in MyD88 −/− mDC cultures but was severely reduced in mDC cultures from mice lacking IFN regulatory factor 3. Our observations suggest that mDCs respond to incoming virus via a pathway that differs from the fusion-independent, MyD88-mediated endosomal pathway described for the induction of IFN-α/β in pDCs. We propose that events during or downstream of viral fusion, but prior to replication, can activate IFN-α/β in mDCs. Thus, mDCs may contribute to the antiviral response activated by the immune system at early time points after infection." @default.
- W2019884119 created "2016-06-24" @default.
- W2019884119 creator A5035302832 @default.
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- W2019884119 creator A5083386185 @default.
- W2019884119 creator A5089160183 @default.
- W2019884119 date "2005-08-15" @default.
- W2019884119 modified "2023-10-01" @default.
- W2019884119 title "Early Alpha/Beta Interferon Production by Myeloid Dendritic Cells in Response to UV-Inactivated Virus Requires Viral Entry and Interferon Regulatory Factor 3 but Not MyD88" @default.
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- W2019884119 doi "https://doi.org/10.1128/jvi.79.16.10376-10385.2005" @default.
- W2019884119 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1182635" @default.
- W2019884119 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16051830" @default.
- W2019884119 hasPublicationYear "2005" @default.
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