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- W2019885557 abstract "scintigraphy demonstrated segmental perfusion abnormalities in 38.5% of the patients. 7 Unfortunately, nuclear studies cannot be used to define the precise cardiac abnormality, because they cannot differentiate large vessel from small vessel disease. To our knowledge, only one other patient with SLE has been reported to have had a myocardial infarction at such a young age. 8 That patient had a 2-year history of SLE and steroid therapy, as well as autopsy findings that revealed severe coronary atherosclerosis and hypertriglyceridemia. In our patient, specific evidence of coronary vasculitis, such as the presence of coronary aneurysms, was not established. However, atherosclerotic heart disease is an unlikely pathogenic mechanism, because blood pressure and serum cholesterol and serum triglyceride values were within normal limits; moreover, active disease and steroid use were limited to 1 month. In the context of a clinical presentation that included evidence of cutaneous and cerebral vasculitis, and in the absence of risk factors for atherosclerotic heart disease, coronary arteritis is the most likely mechanism of myocardial infarction in this patient. Regardless of the mechanism, we conclude that even with short duration of disease, young patients with SLE are subject to cardiac complications, including myocardial infarction. We thank Veronica Schmer, MD, and the pediatric house staff, who provided excellent care to this patient." @default.
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- W2019885557 title "Iron deficiency in children with cyanotic congenital heart disease" @default.
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