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• W2019889712 abstract "Background: Inhibitory effects of roflumilast on responses characteristic of allergic asthma were investigated in a fungal asthma model in BALB/c mice. Methods: Mice were sensitized with Aspergillus antigen (Afu) and exposed to Afu or vehicle, and given roflumilast 1 or 5 mg/kg. Early airway response (EAR) and late airway hyperresponsiveness (AHR) to methacholine were measured via plethysmography. Bronchoalveolar lavage (BAL) was used to assess inflammatory cell count. Results: In Afu-exposed mice, roflumilast dose-dependently reduced the EAR [26% at 1 mg/kg (NS) and 94% at 5 mg/kg (p < 0.01)] and AHR [46% at 1 mg/kg (NS) and 128% at 5 mg/kg (p < 0.05)]. Roflumilast 5 mg/kg reduced neutrophil, eosinophil and lymphocyte counts [87% (p < 0.01), 40% (NS) and 67% (p < 0.01), respectively] in BAL fluid versus controls. Conclusions: In this model, roflumilast inhibited the EAR, suppressed AHR and reduced inflammatory cell infiltration." @default.
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• W2019889712 date "2009-01-01" @default.
• W2019889712 modified "2023-09-25" @default.
• W2019889712 title "Effects of the Phosphodiesterase Type 4 Inhibitor Roflumilast on Early and Late Allergic Response and Airway Hyperresponsiveness in <i>Aspergillus-fumigatus</i>-Sensitized Mice" @default.
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• W2019889712 doi "https://doi.org/10.1159/000196814" @default.
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