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• W2019890187 abstract "McMahon MA, Vargus-Adams JN, Michaud LJ, Bean J: Effects of amantadine in children with impaired consciousness caused by acquired brain injury: A pilot study. Objective: To conduct a pilot study of amantadine in children with impaired consciousness caused by acquired brain injury, to establish design feasibility, and to assess the effect on level of arousal and consciousness. Design: Randomized, double-blind, placebo-controlled crossover trial. Seven subjects (mean age, 12.7 yrs) with an acquired brain injury (mean duration, 6 wks) were randomized to receive either 3 wks of placebo or amantadine, followed by a 1-wk washout period and then 3 wks of the other agent. Main outcome measures were the Coma/Near-Coma Scale and Coma Recovery Scale-Revised, each done three times per week. Subjective evaluations of change in arousal and consciousness by the parent and physician were done weekly. Results: Five subjects completed the study. There was no significant difference in the slopes of recovery during either arm for the Coma/Near-Coma Scale (P = 0.24) or the Coma Recovery Scale-Revised (P = 0.28), although improvements in consciousness were noted by the physician during weeks when amantadine was given (P = 0.02). Conclusions: This study suggests that amantadine facilitates recovery of consciousness in pediatric acquired brain injury and provides important information necessary to design future more definitive studies." @default.
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• W2019890187 date "2009-07-01" @default.
• W2019890187 modified "2023-10-18" @default.
• W2019890187 title "Effects of Amantadine in Children with Impaired Consciousness Caused by Acquired Brain Injury" @default.
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• W2019890187 doi "https://doi.org/10.1097/phm.0b013e3181a5ade3" @default.
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