Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019900293> ?p ?o ?g. }
- W2019900293 endingPage "568" @default.
- W2019900293 startingPage "563" @default.
- W2019900293 abstract "Objective Although failure to achieve an adequate activated coagulation time (ACT) after full heparinization before cardiopulmonary bypass often is attributed to antithrombin (AT) deficiency, it remains unclear if this is a causative mechanism of decreased heparin responsiveness. Therefore, the authors determined the relationship between AT and other coagulation-related factors that affect the ACT measurement and heparin sensitivity index before the establishment of cardiopulmonary bypass. Design Observational study. Setting University medical center. Participants Adult elective cardiac surgical patients. Interventions Preoperative data collection included demographics, type of preoperative medical therapy, hemoglobin, platelet count, and AT. Intraoperative measurements included ACT and anti-Xa activity. Results Of the 203 patients enrolled in this study, 10% (n = 21) did not achieve an adequate ACT (≥400 seconds) after full heparinization. Subnormal AT activity (55%-79%) was not related to a low ACT and a low heparin sensitivity index. Preoperative low-molecular-weight heparin therapy did not cause a decreased ACT response. However, preoperative low hemoglobin levels and high platelet counts were associated with a decreased ACT. Conclusions All these observations suggest that failure to achieve an adequate ACT is, in general, not an indicator of AT deficiency but could be affected by high platelet counts and low hemoglobin levels. Although failure to achieve an adequate activated coagulation time (ACT) after full heparinization before cardiopulmonary bypass often is attributed to antithrombin (AT) deficiency, it remains unclear if this is a causative mechanism of decreased heparin responsiveness. Therefore, the authors determined the relationship between AT and other coagulation-related factors that affect the ACT measurement and heparin sensitivity index before the establishment of cardiopulmonary bypass. Observational study. University medical center. Adult elective cardiac surgical patients. Preoperative data collection included demographics, type of preoperative medical therapy, hemoglobin, platelet count, and AT. Intraoperative measurements included ACT and anti-Xa activity. Of the 203 patients enrolled in this study, 10% (n = 21) did not achieve an adequate ACT (≥400 seconds) after full heparinization. Subnormal AT activity (55%-79%) was not related to a low ACT and a low heparin sensitivity index. Preoperative low-molecular-weight heparin therapy did not cause a decreased ACT response. However, preoperative low hemoglobin levels and high platelet counts were associated with a decreased ACT. All these observations suggest that failure to achieve an adequate ACT is, in general, not an indicator of AT deficiency but could be affected by high platelet counts and low hemoglobin levels." @default.
- W2019900293 created "2016-06-24" @default.
- W2019900293 creator A5000354857 @default.
- W2019900293 creator A5016545357 @default.
- W2019900293 creator A5025025166 @default.
- W2019900293 creator A5069028114 @default.
- W2019900293 creator A5085688118 @default.
- W2019900293 date "2012-08-01" @default.
- W2019900293 modified "2023-10-03" @default.
- W2019900293 title "An Evaluation of Factors Affecting Activated Coagulation Time" @default.
- W2019900293 cites W133116715 @default.
- W2019900293 cites W1489758714 @default.
- W2019900293 cites W1527418628 @default.
- W2019900293 cites W1548208729 @default.
- W2019900293 cites W1786317249 @default.
- W2019900293 cites W1813018921 @default.
- W2019900293 cites W1968494904 @default.
- W2019900293 cites W1970986511 @default.
- W2019900293 cites W1989940253 @default.
- W2019900293 cites W1992566097 @default.
- W2019900293 cites W2002873925 @default.
- W2019900293 cites W2004142847 @default.
- W2019900293 cites W2005798908 @default.
- W2019900293 cites W2008497214 @default.
- W2019900293 cites W2026599765 @default.
- W2019900293 cites W2041356216 @default.
- W2019900293 cites W2050790964 @default.
- W2019900293 cites W2070791402 @default.
- W2019900293 cites W2073452994 @default.
- W2019900293 cites W2075196907 @default.
- W2019900293 cites W2077011119 @default.
- W2019900293 cites W2078279064 @default.
- W2019900293 cites W2080318130 @default.
- W2019900293 cites W2088976278 @default.
- W2019900293 cites W2091242480 @default.
- W2019900293 cites W2097318988 @default.
- W2019900293 cites W2103340294 @default.
- W2019900293 cites W2117133868 @default.
- W2019900293 cites W2126258404 @default.
- W2019900293 cites W2132391133 @default.
- W2019900293 cites W2134434275 @default.
- W2019900293 cites W2322949862 @default.
- W2019900293 cites W2326872281 @default.
- W2019900293 cites W2416007221 @default.
- W2019900293 cites W4210663131 @default.
- W2019900293 cites W4244226712 @default.
- W2019900293 cites W4251635256 @default.
- W2019900293 doi "https://doi.org/10.1053/j.jvca.2012.03.011" @default.
- W2019900293 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22534410" @default.
- W2019900293 hasPublicationYear "2012" @default.
- W2019900293 type Work @default.
- W2019900293 sameAs 2019900293 @default.
- W2019900293 citedByCount "8" @default.
- W2019900293 countsByYear W20199002932013 @default.
- W2019900293 countsByYear W20199002932015 @default.
- W2019900293 countsByYear W20199002932016 @default.
- W2019900293 countsByYear W20199002932020 @default.
- W2019900293 countsByYear W20199002932021 @default.
- W2019900293 countsByYear W20199002932022 @default.
- W2019900293 countsByYear W20199002932023 @default.
- W2019900293 crossrefType "journal-article" @default.
- W2019900293 hasAuthorship W2019900293A5000354857 @default.
- W2019900293 hasAuthorship W2019900293A5016545357 @default.
- W2019900293 hasAuthorship W2019900293A5025025166 @default.
- W2019900293 hasAuthorship W2019900293A5069028114 @default.
- W2019900293 hasAuthorship W2019900293A5085688118 @default.
- W2019900293 hasConcept C126322002 @default.
- W2019900293 hasConcept C141071460 @default.
- W2019900293 hasConcept C144024400 @default.
- W2019900293 hasConcept C149923435 @default.
- W2019900293 hasConcept C16124881 @default.
- W2019900293 hasConcept C164705383 @default.
- W2019900293 hasConcept C177713679 @default.
- W2019900293 hasConcept C2777557582 @default.
- W2019900293 hasConcept C2777987278 @default.
- W2019900293 hasConcept C2778205648 @default.
- W2019900293 hasConcept C2778382381 @default.
- W2019900293 hasConcept C2778881276 @default.
- W2019900293 hasConcept C2779026020 @default.
- W2019900293 hasConcept C2780084366 @default.
- W2019900293 hasConcept C3018697912 @default.
- W2019900293 hasConcept C42219234 @default.
- W2019900293 hasConcept C71924100 @default.
- W2019900293 hasConcept C89560881 @default.
- W2019900293 hasConceptScore W2019900293C126322002 @default.
- W2019900293 hasConceptScore W2019900293C141071460 @default.
- W2019900293 hasConceptScore W2019900293C144024400 @default.
- W2019900293 hasConceptScore W2019900293C149923435 @default.
- W2019900293 hasConceptScore W2019900293C16124881 @default.
- W2019900293 hasConceptScore W2019900293C164705383 @default.
- W2019900293 hasConceptScore W2019900293C177713679 @default.
- W2019900293 hasConceptScore W2019900293C2777557582 @default.
- W2019900293 hasConceptScore W2019900293C2777987278 @default.
- W2019900293 hasConceptScore W2019900293C2778205648 @default.
- W2019900293 hasConceptScore W2019900293C2778382381 @default.
- W2019900293 hasConceptScore W2019900293C2778881276 @default.
- W2019900293 hasConceptScore W2019900293C2779026020 @default.
- W2019900293 hasConceptScore W2019900293C2780084366 @default.