Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019900313> ?p ?o ?g. }
- W2019900313 endingPage "783" @default.
- W2019900313 startingPage "776" @default.
- W2019900313 abstract "Abstract Type 2 diabetes mellitus (T2DM) being a worldwide challenge to public health. The aim of this study was to examine the effect of esculetin, a major compound present in the herbal plant of Matricaria chamomilla L., on the key enzymes of carbohydrate metabolism in streptozotocin (STZ) induced diabetic rats. At first, the rats were induced intraperitonial injection of STZ (40 mg/kg bw) to attain diabetes and were then treated with different concentrations of esculetin (10, 20 and 40 mg/kg bw) for 45 days. The diabetic rats had elevated levels of plasma glucose and glycated haemoglobin (HbA1c) and decreased plasma insulin and haemoglobin (Hb) levels. Food intake, water intake and oral glucose tolerance test were also measured. Activities of carbohydrate metabolic enzymes such as glucose-6-phosphatase, fructose 1,6-bisphosphatase increased and glucokinase, glucose-6-phosphate dehydrogenase decreased significantly. Oral administration of esculetin significantly decreased the levels of plasma glucose, HbA1c and increased the levels of Hb and insulin. The activities of the key enzymes such as glucokinase and glucose-6-phosphate dehydrogenase had significantly increased whereas, glucose-6-phosphatase and fructose-1,6-bisphosphatase had significantly decreased. Further, protection against body weight loss of diabetic rats was observed. Among the three doses, 40 mg/kg bw of esculetin exerted a more pronounced antihyperglycemic effect against STZ-induced diabetic rats." @default.
- W2019900313 created "2016-06-24" @default.
- W2019900313 creator A5012696874 @default.
- W2019900313 creator A5081758455 @default.
- W2019900313 date "2012-10-01" @default.
- W2019900313 modified "2023-10-01" @default.
- W2019900313 title "Antihyperglycemic effect of esculetin modulated carbohydrate metabolic enzymes activities in streptozotocin induced diabetic rats" @default.
- W2019900313 cites W1486993464 @default.
- W2019900313 cites W1797186306 @default.
- W2019900313 cites W1964285340 @default.
- W2019900313 cites W1964720050 @default.
- W2019900313 cites W1968998478 @default.
- W2019900313 cites W1969824339 @default.
- W2019900313 cites W1988719208 @default.
- W2019900313 cites W1989089243 @default.
- W2019900313 cites W1990089345 @default.
- W2019900313 cites W1992257277 @default.
- W2019900313 cites W1992897215 @default.
- W2019900313 cites W2001444091 @default.
- W2019900313 cites W2007345457 @default.
- W2019900313 cites W2011073664 @default.
- W2019900313 cites W2021899336 @default.
- W2019900313 cites W2023774171 @default.
- W2019900313 cites W2028377558 @default.
- W2019900313 cites W2033453118 @default.
- W2019900313 cites W2040255703 @default.
- W2019900313 cites W2044396378 @default.
- W2019900313 cites W2046740976 @default.
- W2019900313 cites W2049203909 @default.
- W2019900313 cites W2053616715 @default.
- W2019900313 cites W2062636861 @default.
- W2019900313 cites W2064258141 @default.
- W2019900313 cites W2069726770 @default.
- W2019900313 cites W2072511243 @default.
- W2019900313 cites W2079734741 @default.
- W2019900313 cites W2082209113 @default.
- W2019900313 cites W2083031489 @default.
- W2019900313 cites W2093489618 @default.
- W2019900313 cites W2097757455 @default.
- W2019900313 cites W2104422156 @default.
- W2019900313 cites W2116032635 @default.
- W2019900313 cites W2124695577 @default.
- W2019900313 cites W2126317966 @default.
- W2019900313 cites W2151630485 @default.
- W2019900313 cites W2151716122 @default.
- W2019900313 cites W2161163021 @default.
- W2019900313 cites W2166737913 @default.
- W2019900313 cites W2168457230 @default.
- W2019900313 cites W2209770937 @default.
- W2019900313 cites W2253864316 @default.
- W2019900313 cites W2334642891 @default.
- W2019900313 cites W2346149142 @default.
- W2019900313 cites W4232138652 @default.
- W2019900313 doi "https://doi.org/10.1016/j.jff.2012.05.005" @default.
- W2019900313 hasPublicationYear "2012" @default.
- W2019900313 type Work @default.
- W2019900313 sameAs 2019900313 @default.
- W2019900313 citedByCount "37" @default.
- W2019900313 countsByYear W20199003132013 @default.
- W2019900313 countsByYear W20199003132014 @default.
- W2019900313 countsByYear W20199003132015 @default.
- W2019900313 countsByYear W20199003132016 @default.
- W2019900313 countsByYear W20199003132017 @default.
- W2019900313 countsByYear W20199003132018 @default.
- W2019900313 countsByYear W20199003132019 @default.
- W2019900313 countsByYear W20199003132020 @default.
- W2019900313 countsByYear W20199003132021 @default.
- W2019900313 countsByYear W20199003132022 @default.
- W2019900313 countsByYear W20199003132023 @default.
- W2019900313 crossrefType "journal-article" @default.
- W2019900313 hasAuthorship W2019900313A5012696874 @default.
- W2019900313 hasAuthorship W2019900313A5081758455 @default.
- W2019900313 hasConcept C134018914 @default.
- W2019900313 hasConcept C181199279 @default.
- W2019900313 hasConcept C185592680 @default.
- W2019900313 hasConcept C2778977261 @default.
- W2019900313 hasConcept C2779280383 @default.
- W2019900313 hasConcept C55493867 @default.
- W2019900313 hasConcept C555293320 @default.
- W2019900313 hasConcept C71924100 @default.
- W2019900313 hasConcept C98274493 @default.
- W2019900313 hasConceptScore W2019900313C134018914 @default.
- W2019900313 hasConceptScore W2019900313C181199279 @default.
- W2019900313 hasConceptScore W2019900313C185592680 @default.
- W2019900313 hasConceptScore W2019900313C2778977261 @default.
- W2019900313 hasConceptScore W2019900313C2779280383 @default.
- W2019900313 hasConceptScore W2019900313C55493867 @default.
- W2019900313 hasConceptScore W2019900313C555293320 @default.
- W2019900313 hasConceptScore W2019900313C71924100 @default.
- W2019900313 hasConceptScore W2019900313C98274493 @default.
- W2019900313 hasIssue "4" @default.
- W2019900313 hasLocation W20199003131 @default.
- W2019900313 hasOpenAccess W2019900313 @default.
- W2019900313 hasPrimaryLocation W20199003131 @default.
- W2019900313 hasRelatedWork W1563850031 @default.
- W2019900313 hasRelatedWork W2033297571 @default.
- W2019900313 hasRelatedWork W2078181680 @default.
- W2019900313 hasRelatedWork W2383009242 @default.