Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019900356> ?p ?o ?g. }
Showing items 1 to 56 of
56
with 100 items per page.
- W2019900356 endingPage "19" @default.
- W2019900356 startingPage "18" @default.
- W2019900356 abstract "Brain oscillatory responses can be used for non-invasive analyses of cortico-cortical connectivity, local neuronal synchronization, and coherence of oscillations in many neuropsychiatric conditions including Alzheimer's disease (AD). In the present paper, we examine sensory-evoked and event-related gamma coherences elicited by visual stimuli in three sub-gamma bands in two sub-groups of patients with AD (i.e., acetylcholinesterase-inhibitor treated and untreated) and healthy controls.We studied a total of 39 patients with probable mild AD (according to NINCDS-ADRDA criteria) who had been sub-divided into untreated (n = 21) and treated (n = 18) (patients either on cholinergic monotherapy or combined therapy with memantine) AD groups, and 21 age-, gender-, and education-matched healthy elderly controls. A simple flash visual paradigm was applied for the acquisition of sensory-evoked coherences. Event-related coherences were elicited using a classical visual oddball paradigm. Both sensory-evoked and event-related gamma coherences were calculated for long-distance intrahemispheric pairs for three frequency ranges: 25–30 Hz, 30–35 Hz, and 40–48 Hz in post-stimulus 0–800 ms duration. The long-distance intrahemispheric pairs from both sides were fronto-parietal, fronto-temporal, fronto-temporoparietal, fronto-occipital, centro-occipital and parieto-occipital.The sensory-evoked or event-related gamma coherences revealed that both treated and untreated AD patients had significantly increased values compared to healthy controls in all three sub-gamma bands. Moreover, the treated AD patients demonstrated significantly higher fronto-parietal gamma coherences during both sensory stimulation and oddball paradigm and lower occipito-parietal coherences during oddball paradigm in comparison to untreated AD patients.The present study demonstrated that an increase of gamma coherences was present in response to both visual sensory and cognitive stimulation in AD patients in all gamma sub-bands. Therefore, gamma oscillatory activity seems to be fundamental in brain functions at both the sensory and cognitive levels. The increase of gamma coherence values was not due to cholinergic treatment to any significant extent, as both treated and untreated AD patients had increased gamma coherence values compared to healthy controls. The use of coherence values reflecting brain connectivity holds potential for neuroimaging of AD and understanding brain dynamics related to the effects of medication." @default.
- W2019900356 created "2016-06-24" @default.
- W2019900356 creator A5021264445 @default.
- W2019900356 creator A5028187108 @default.
- W2019900356 creator A5091796281 @default.
- W2019900356 date "1987-05-01" @default.
- W2019900356 modified "2023-09-25" @default.
- W2019900356 title "51. Dopamine and homovanillic acid concentrations and monoamine oxidase-B activities in the brain tissue of patients with Alzheimer's disease" @default.
- W2019900356 doi "https://doi.org/10.1016/0303-8467(87)90051-5" @default.
- W2019900356 hasPublicationYear "1987" @default.
- W2019900356 type Work @default.
- W2019900356 sameAs 2019900356 @default.
- W2019900356 citedByCount "0" @default.
- W2019900356 crossrefType "journal-article" @default.
- W2019900356 hasAuthorship W2019900356A5021264445 @default.
- W2019900356 hasAuthorship W2019900356A5028187108 @default.
- W2019900356 hasAuthorship W2019900356A5091796281 @default.
- W2019900356 hasConcept C15744967 @default.
- W2019900356 hasConcept C169760540 @default.
- W2019900356 hasConcept C22334291 @default.
- W2019900356 hasConcept C42219234 @default.
- W2019900356 hasConcept C522805319 @default.
- W2019900356 hasConcept C548259974 @default.
- W2019900356 hasConcept C67359045 @default.
- W2019900356 hasConcept C71924100 @default.
- W2019900356 hasConcept C94487597 @default.
- W2019900356 hasConceptScore W2019900356C15744967 @default.
- W2019900356 hasConceptScore W2019900356C169760540 @default.
- W2019900356 hasConceptScore W2019900356C22334291 @default.
- W2019900356 hasConceptScore W2019900356C42219234 @default.
- W2019900356 hasConceptScore W2019900356C522805319 @default.
- W2019900356 hasConceptScore W2019900356C548259974 @default.
- W2019900356 hasConceptScore W2019900356C67359045 @default.
- W2019900356 hasConceptScore W2019900356C71924100 @default.
- W2019900356 hasConceptScore W2019900356C94487597 @default.
- W2019900356 hasIssue "2" @default.
- W2019900356 hasLocation W20199003561 @default.
- W2019900356 hasOpenAccess W2019900356 @default.
- W2019900356 hasPrimaryLocation W20199003561 @default.
- W2019900356 hasRelatedWork W2003156394 @default.
- W2019900356 hasRelatedWork W2046034715 @default.
- W2019900356 hasRelatedWork W2076840247 @default.
- W2019900356 hasRelatedWork W2170111895 @default.
- W2019900356 hasRelatedWork W2531679454 @default.
- W2019900356 hasRelatedWork W2956782247 @default.
- W2019900356 hasRelatedWork W2970198181 @default.
- W2019900356 hasRelatedWork W4232158107 @default.
- W2019900356 hasRelatedWork W4308203215 @default.
- W2019900356 hasRelatedWork W16401255 @default.
- W2019900356 hasVolume "89" @default.
- W2019900356 isParatext "false" @default.
- W2019900356 isRetracted "false" @default.
- W2019900356 magId "2019900356" @default.
- W2019900356 workType "article" @default.