FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019900422> ?p ?o ?g. }

• W2019900422 endingPage "32" @default.
• W2019900422 startingPage "23" @default.
• W2019900422 abstract "Zebrafish embryos are a model for studying effects of environmental stressors on development. Incomplete combustion of the environmentally relevant volatile petrochemical, 1,3-butadiene (BD) yields butadiene soot (BDS) nanoparticles, to which polynuclear aromatic hydrocarbons (PAHs) are adsorbed. In mammalian cells these PAHs are concentrated in lipid droplets and trigger up-regulation of biotransformation, oxidative stress and inflammatory genes. The present study was designed to determine whether: (a) PAH-rich BDS elicits alterations in zebrafish embryo development; (b) BDS-exposed zebrafish embryos sequester PAHs in select tissues; and (c) developmental abnormalities are correlated with altered gene expression patterns. 1-day old zebrafish embryos were exposed for 48 h to BDS (0, 6, 30 or 60 μg/ml) sprinkled on the water surface. PAH localization was tracked by fluorescence. Developmental responses (pericardial edema, yolk sac swelling, axial malformations) were monitored by microscopy. Gene expression changes were assessed by gene microarray and qRT-PCR. Our results show that PAHs localized with endogenous lipids in the yolk sac and in hatching gland cells. PAHs were retained at least 8 days after exposures ended. Dose-dependent pericardial and yolk sac edema and axial malformations were prominent and accompanied by up-regulation of biotransformation and oxidative stress gene cascades. Thus, zebrafish embryos should be useful for predicting the potential for developmental toxicity following exposure to PAH-rich petrochemical soots, e.g., those arising from attempts at oil spill remediation by combustion." @default.
• W2019900422 created "2016-06-24" @default.
• W2019900422 creator A5002077646 @default.
• W2019900422 creator A5003033122 @default.
• W2019900422 creator A5015691642 @default.
• W2019900422 creator A5017827064 @default.
• W2019900422 creator A5063139180 @default.
• W2019900422 date "2012-02-01" @default.
• W2019900422 modified "2023-10-01" @default.
• W2019900422 title "Zebrafish embryos sequester and retain petrochemical combustion products: Developmental and transcriptome consequences" @default.
• W2019900422 cites W1966594837 @default.
• W2019900422 cites W1972778003 @default.
• W2019900422 cites W1976136891 @default.
• W2019900422 cites W1980699864 @default.
• W2019900422 cites W1985716327 @default.
• W2019900422 cites W1985771189 @default.
• W2019900422 cites W1988207207 @default.
• W2019900422 cites W1990131329 @default.
• W2019900422 cites W1997372980 @default.
• W2019900422 cites W1998022726 @default.
• W2019900422 cites W2005254199 @default.
• W2019900422 cites W2007734820 @default.
• W2019900422 cites W2008326203 @default.
• W2019900422 cites W2008486321 @default.
• W2019900422 cites W2014179406 @default.
• W2019900422 cites W2023899667 @default.
• W2019900422 cites W2024093804 @default.
• W2019900422 cites W2025219973 @default.
• W2019900422 cites W2028089759 @default.
• W2019900422 cites W2029002163 @default.
• W2019900422 cites W2031900188 @default.
• W2019900422 cites W2034678923 @default.
• W2019900422 cites W2040674242 @default.
• W2019900422 cites W2043157713 @default.
• W2019900422 cites W2044362554 @default.
• W2019900422 cites W2050607897 @default.
• W2019900422 cites W2052078289 @default.
• W2019900422 cites W2061066399 @default.
• W2019900422 cites W2070477702 @default.
• W2019900422 cites W2071573213 @default.
• W2019900422 cites W2075673711 @default.
• W2019900422 cites W2079943574 @default.
• W2019900422 cites W2086066564 @default.
• W2019900422 cites W2092466223 @default.
• W2019900422 cites W2095522073 @default.
• W2019900422 cites W2098445865 @default.
• W2019900422 cites W2099777262 @default.
• W2019900422 cites W2109192557 @default.
• W2019900422 cites W2117731241 @default.
• W2019900422 cites W2125349610 @default.
• W2019900422 cites W2125491749 @default.
• W2019900422 cites W2129004658 @default.
• W2019900422 cites W2134285628 @default.
• W2019900422 cites W2153947402 @default.
• W2019900422 cites W2156902602 @default.
• W2019900422 cites W2157119187 @default.
• W2019900422 cites W2163138997 @default.
• W2019900422 cites W2169433668 @default.
• W2019900422 cites W4254664638 @default.
• W2019900422 cites W4254894726 @default.
• W2019900422 cites W67988900 @default.
• W2019900422 doi "https://doi.org/10.1016/j.aquatox.2011.09.025" @default.
• W2019900422 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22055752" @default.
• W2019900422 hasPublicationYear "2012" @default.
• W2019900422 type Work @default.
• W2019900422 sameAs 2019900422 @default.
• W2019900422 citedByCount "18" @default.
• W2019900422 countsByYear W20199004222012 @default.
• W2019900422 countsByYear W20199004222014 @default.
• W2019900422 countsByYear W20199004222016 @default.
• W2019900422 countsByYear W20199004222017 @default.
• W2019900422 countsByYear W20199004222019 @default.
• W2019900422 countsByYear W20199004222021 @default.
• W2019900422 countsByYear W20199004222022 @default.
• W2019900422 crossrefType "journal-article" @default.
• W2019900422 hasAuthorship W2019900422A5002077646 @default.
• W2019900422 hasAuthorship W2019900422A5003033122 @default.
• W2019900422 hasAuthorship W2019900422A5015691642 @default.
• W2019900422 hasAuthorship W2019900422A5017827064 @default.
• W2019900422 hasAuthorship W2019900422A5063139180 @default.
• W2019900422 hasConcept C104317684 @default.
• W2019900422 hasConcept C107872376 @default.
• W2019900422 hasConcept C150194340 @default.
• W2019900422 hasConcept C162317418 @default.
• W2019900422 hasConcept C16685009 @default.
• W2019900422 hasConcept C179335377 @default.
• W2019900422 hasConcept C185592680 @default.
• W2019900422 hasConcept C196843134 @default.
• W2019900422 hasConcept C2776151105 @default.
• W2019900422 hasConcept C2776878037 @default.
• W2019900422 hasConcept C2777043721 @default.
• W2019900422 hasConcept C2779234561 @default.
• W2019900422 hasConcept C2781321622 @default.
• W2019900422 hasConcept C31903555 @default.
• W2019900422 hasConcept C46973012 @default.
• W2019900422 hasConcept C54355233 @default.
• W2019900422 hasConcept C55493867 @default.
• W2019900422 hasConcept C71924100 @default.

• next