FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019900787> ?p ?o ?g. }

• W2019900787 endingPage "1760" @default.
• W2019900787 startingPage "1760" @default.
• W2019900787 abstract "Alzheimer disease (AD), which is characterized by progressive cognitive and behavioral deficit, is the most common form of dementia. The incidence of AD is increasing at an alarming rate, and has become a major public health concern in many countries. It is well known that the onset of AD is preceded by a long preclinical period. It is thus critical to establish diagnostic biomarkers that can predict the risk of developing AD prior to clinical manifestation of dementia, for effective prevention and early intervention. With the emergence of potential promising approaches to treat AD targeting the beta-amyloid (Abeta) pathway, such as gamma-secretase inhibitors and vaccine therapy, there is an urgent need for such diagnostic markers. Although cerebrospinal fluid (CSF) Abeta and tau protein levels are candidate biomarkers for AD, the invasive sampling procedure with associated complications limits their use in routine clinical practice. Plasma Abeta has been suggested as an inexpensive and non-invasive biomarker for AD. Although most previous cross-sectional studies on plasma Abeta level in humans failed to show a significant difference between individuals with AD compared to healthy older adults, many strategies are under investigation to improve the diagnostic potential of plasma Abeta. One promising approach is to modify the plasma Abeta level using some potential modulators. It is possible that a difference in plasma Abeta level might be unmasked by evaluating the response to stimulation by a modulator. Anti-Abeta antibody and Abeta binding proteins have been reported to be such modulators of plasma Abeta. In addition, the glucometabolic or hormonal status appears to modulate the plasma Abeta level. Our recent study has shown the possibility that glucose loading could be a novel simple strategy to modulate the plasma Abeta level, making it better suited for early diagnosis. This review summarizes the utility and limitations of current biomarkers of AD and discusses future strategies to improve the diagnostic potential of plasma Abeta." @default.
• W2019900787 created "2016-06-24" @default.
• W2019900787 creator A5010101317 @default.
• W2019900787 creator A5021267745 @default.
• W2019900787 creator A5025005882 @default.
• W2019900787 creator A5068120492 @default.
• W2019900787 date "2010-01-01" @default.
• W2019900787 modified "2023-10-16" @default.
• W2019900787 title "Plasma β-amyloid as potential biomarker of Alzheimer disease: possibility of diagnostic tool for Alzheimer disease" @default.
• W2019900787 cites W1575230904 @default.
• W2019900787 cites W1644122431 @default.
• W2019900787 cites W1796916475 @default.
• W2019900787 cites W1819221371 @default.
• W2019900787 cites W1963669299 @default.
• W2019900787 cites W1963889055 @default.
• W2019900787 cites W1965214584 @default.
• W2019900787 cites W1966613471 @default.
• W2019900787 cites W1967549235 @default.
• W2019900787 cites W1974604086 @default.
• W2019900787 cites W1976048196 @default.
• W2019900787 cites W1978290642 @default.
• W2019900787 cites W1980099228 @default.
• W2019900787 cites W1992758695 @default.
• W2019900787 cites W1994580857 @default.
• W2019900787 cites W1996799369 @default.
• W2019900787 cites W1998547246 @default.
• W2019900787 cites W1999620600 @default.
• W2019900787 cites W2000291174 @default.
• W2019900787 cites W2004531476 @default.
• W2019900787 cites W2013333500 @default.
• W2019900787 cites W2014454308 @default.
• W2019900787 cites W2016484007 @default.
• W2019900787 cites W2016698723 @default.
• W2019900787 cites W2017199725 @default.
• W2019900787 cites W2017779103 @default.
• W2019900787 cites W2025935592 @default.
• W2019900787 cites W2027136096 @default.
• W2019900787 cites W2030182984 @default.
• W2019900787 cites W2031441539 @default.
• W2019900787 cites W2032920422 @default.
• W2019900787 cites W2036450484 @default.
• W2019900787 cites W2037855506 @default.
• W2019900787 cites W2042902316 @default.
• W2019900787 cites W2044133891 @default.
• W2019900787 cites W2045148031 @default.
• W2019900787 cites W2046008470 @default.
• W2019900787 cites W2046952010 @default.
• W2019900787 cites W2050607653 @default.
• W2019900787 cites W2054995979 @default.
• W2019900787 cites W2056099151 @default.
• W2019900787 cites W2057960819 @default.
• W2019900787 cites W2058614488 @default.
• W2019900787 cites W2065184319 @default.
• W2019900787 cites W2067960064 @default.
• W2019900787 cites W2068781633 @default.
• W2019900787 cites W2073813663 @default.
• W2019900787 cites W2074859138 @default.
• W2019900787 cites W2075193321 @default.
• W2019900787 cites W2076606883 @default.
• W2019900787 cites W2077756886 @default.
• W2019900787 cites W2077966741 @default.
• W2019900787 cites W2078052928 @default.
• W2019900787 cites W2079402113 @default.
• W2019900787 cites W2081140305 @default.
• W2019900787 cites W2083045535 @default.
• W2019900787 cites W2083984027 @default.
• W2019900787 cites W2087574229 @default.
• W2019900787 cites W2094777896 @default.
• W2019900787 cites W2096410114 @default.
• W2019900787 cites W2099570666 @default.
• W2019900787 cites W2100225574 @default.
• W2019900787 cites W2101077392 @default.
• W2019900787 cites W2102481823 @default.
• W2019900787 cites W2104591424 @default.
• W2019900787 cites W2105631420 @default.
• W2019900787 cites W2107233754 @default.
• W2019900787 cites W2111883514 @default.
• W2019900787 cites W2129379145 @default.
• W2019900787 cites W2129659920 @default.
• W2019900787 cites W2130079515 @default.
• W2019900787 cites W2130286883 @default.
• W2019900787 cites W2133019124 @default.
• W2019900787 cites W2133595485 @default.
• W2019900787 cites W2135955724 @default.
• W2019900787 cites W2139242905 @default.
• W2019900787 cites W2142090603 @default.
• W2019900787 cites W2146417109 @default.
• W2019900787 cites W2147177629 @default.
• W2019900787 cites W2154705555 @default.
• W2019900787 cites W2160250384 @default.
• W2019900787 cites W2166142595 @default.
• W2019900787 cites W2295393683 @default.
• W2019900787 cites W4241053551 @default.
• W2019900787 doi "https://doi.org/10.1039/c003148h" @default.
• W2019900787 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20567751" @default.
• W2019900787 hasPublicationYear "2010" @default.
• W2019900787 type Work @default.
• W2019900787 sameAs 2019900787 @default.

• next