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- W2019900906 abstract "An attempt has been made to classify the coronary vascular β-adrenoceptors as ‘β1’ or ‘β2’ by studying the effect of 3 different β-blocking agents on the isoprenaline-induced relaxation of isolated strips of pig coronary arteries. The study includes propranolol as a potent blocker of both cardiac and peripheral vascular β-adrenoceptors, H 93/26, 1-isopropylamino-3-[4-(2-methoxyethyl)-phenoxyl]-2-propanol, as a ‘cardioselective’ β-blocker, and H 35/25, 2-isopropylamino-1-(4-methylphenyl)- 1-propanol, as a blocker with predominant action on the peripheral adrenoceptors. The differential influence of the latter 2 substances is illustrated by experiments on isolated rat atria and rat portal veins. The coronary artery strips resembled the atrial effectors in their sensitivity to all 3 blockers but they differed from the venous smooth muscle. It is suggested that the β-adrenoceptors of the coronary arteries should be placed in the β1 category." @default.
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- W2019900906 date "1973-11-01" @default.
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- W2019900906 title "The β-adrenoceptors in the smooth muscle of pig coronary arteries" @default.
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- W2019900906 doi "https://doi.org/10.1016/0014-2999(73)90075-7" @default.
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