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- W2019901662 abstract "A carcinoid tumor of the peripheral lung producing gastrin-releasing peptide (GRP), a peptide hormone known to be present in the endocrine cells of fetal bronchial epithelium, is reported. Brain-gut peptide hormones in this tumor were assayed by radioimmunoassays, localized by immunohistochemistry and characterized by gel filtration. Electron microscopic study revealed that tumor cells resembled P-cells of normal human fetal bronchial epithelium. While GRP-containing cells were predominant in this tumor, calcitonin-containing cells were also found in some areas. Difference in distribution of hormones according to histologic features was noted in the tumor. A greater portion of the tumor showed spindled cells that predominantly contained GRP, and a smaller portion of the tumor showed cells arranged in tubular or trabecular patterns that mainly contained calcitonin. The gel-filtration pattern of the tumor extracts consisted of two peaks, one of these corresponded to the synthetic replicate of porcine GRP, and another was considered to correspond to C-terminal fragments of the peptide." @default.
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- W2019901662 date "1983-07-15" @default.
- W2019901662 modified "2023-09-24" @default.
- W2019901662 title "Peripheral lung carcinoid tumor producing predominantly gastrin-releasing peptide (GRP) morphologic and hormonal studies" @default.
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- W2019901662 doi "https://doi.org/10.1002/1097-0142(19830715)52:2<273::aid-cncr2820520214>3.0.co;2-k" @default.
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