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- W2019903132 abstract "The effects of repeated administration of levoprotiline, a novel type of tetracyclic antidepressant on histamine H1, muscarinic acetylcholine and α1-adrenergic receptors and the response of phosphoinositide hydrolysis (PI) stimulated by histamine in the cortex of the rat brain were investigated. Histamine H1 receptors were up-regulated to 120% and PI response stimulated by histamine was enhanced to 160%–200% after repeated treatment with levoprotiline (20mg/kg, i.p., once a day for 28 days) when compared to that of the saline-treated group. No significant alterations of muscarinic acetylcholine and α1-adrenergic receptors were observed. This demonstrates that the repeated treatment with levoprotiline has prominent action on the regulation of histamine H1 receptors and PI response coupling to histamine H1 receptors in vivo." @default.
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- W2019903132 title "Repeated Treatment with Levoprotiline, a Novel Antidepressant, Up-Regulates Histamine Hi Receptors and Phosphoinositide Hydrolysis Response In Vivo" @default.
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- W2019903132 doi "https://doi.org/10.1254/jjp.59.31" @default.
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