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• W2019904197 abstract "The transcription factor NURR1 plays a pivotal role in the development and maintenance of neurotransmitter phenotype in midbrain dopamine neurons. Conversely, decreased NURR1 expression is associated with a number of dopamine-related CNS disorders, including Parkinson's disease and drug addiction. In order to better understand the nature of NURR1-responsive genes and their potential roles in dopamine neuron differentiation and survival, we used a human neural cellular background (SK-N-AS cells) in which to generate a number of stable clonal lines with graded NURR1 gene expression that approximated that seen in DA cell-rich human substantia nigra. Gene expression profiling data from these NURR1-expressing clonal lines were validated by quantitative RT-PCR and subjected to bioinformatic analyses. The present study identified a large number of NURR1-responsive genes and demonstrated the potential importance of concentration-dependent NURR1 effects in the differential regulation of distinct NURR1 target genes and biological pathways. These data support the promise of NURR1-based CNS therapeutics for the neuroprotection and/or functional restoration of DA neurons." @default.
• W2019904197 created "2016-06-24" @default.
• W2019904197 creator A5085846904 @default.
• W2019904197 date "2011-01-01" @default.
• W2019904197 modified "2023-10-16" @default.
• W2019904197 title "The transcription factor NURR1 exerts concentration-dependent effects on target genes mediating distinct biological processes" @default.
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• W2019904197 doi "https://doi.org/10.3389/fnins.2011.00135" @default.
• W2019904197 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3243378" @default.
• W2019904197 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22194714" @default.
• W2019904197 hasPublicationYear "2011" @default.
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