Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019904224> ?p ?o ?g. }
- W2019904224 endingPage "243" @default.
- W2019904224 startingPage "233" @default.
- W2019904224 abstract "The incidence of asthma is increasing throughout the world, which presents both public health and economic concerns. It is widely recognized that in some adult patients with asthma, aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) that inhibit cyclooxygenase (COX)-1 exacerbate the condition. This is a distinct clinical syndrome called aspirin-induced asthma (AIA). The disease develops according to a characteristic pattern of symptoms. Persistent eosinophilic rhinosinusitis precedes development of nasal polyposis, aspirin hypersensitivity, and asthma. There is no in vitro test, and diagnosis can only be established by provocation tests with aspirin. At the biochemical level, AIA is characterized by a chronic overproduction of cysteinyl leukotrienes. The key enzyme, leukotriene C4 synthase, is overexpressed in bronchi, and its messenger RNA is upregulated in peripheral blood eosinophils. This can be partly related to the genetic polymorphism of the enzyme. The disease runs a protracted course, even if COX-1 inhibitors are avoided. The course of AIA is often severe, and at least half of the patients need systemic corticosteroids to control their asthma. To prevent life-threatening reactions, patients with AIA should avoid aspirin and other analgesics that inhibit COX-1. The incidence of cross-sensitivity to paracetamol in AIA patients is low and, when a reaction does occur, the symptoms experienced are shorter and milder than if the reactions were evoked by an NSAID. Rapidly growing evidence indicates that highly specific COX-2 inhibitors, known as coxibs, are well tolerated and can be safely used by AIA patients." @default.
- W2019904224 created "2016-06-24" @default.
- W2019904224 creator A5002242536 @default.
- W2019904224 creator A5017061318 @default.
- W2019904224 creator A5037141001 @default.
- W2019904224 creator A5056829425 @default.
- W2019904224 date "2002-05-01" @default.
- W2019904224 modified "2023-09-25" @default.
- W2019904224 title "Analgesics and Asthma" @default.
- W2019904224 cites W1529549908 @default.
- W2019904224 cites W153805445 @default.
- W2019904224 cites W1588075129 @default.
- W2019904224 cites W1588506026 @default.
- W2019904224 cites W1948059877 @default.
- W2019904224 cites W1972456290 @default.
- W2019904224 cites W1977473142 @default.
- W2019904224 cites W1979169522 @default.
- W2019904224 cites W1979655911 @default.
- W2019904224 cites W1982840989 @default.
- W2019904224 cites W1983711608 @default.
- W2019904224 cites W1986219984 @default.
- W2019904224 cites W1987004171 @default.
- W2019904224 cites W1990063987 @default.
- W2019904224 cites W1990174772 @default.
- W2019904224 cites W1997712398 @default.
- W2019904224 cites W1998913833 @default.
- W2019904224 cites W2001162433 @default.
- W2019904224 cites W2002058751 @default.
- W2019904224 cites W2004293605 @default.
- W2019904224 cites W2005685486 @default.
- W2019904224 cites W2006162058 @default.
- W2019904224 cites W2007357379 @default.
- W2019904224 cites W2010639117 @default.
- W2019904224 cites W2010967782 @default.
- W2019904224 cites W2011699058 @default.
- W2019904224 cites W2012447142 @default.
- W2019904224 cites W2012938039 @default.
- W2019904224 cites W2013538617 @default.
- W2019904224 cites W2015014078 @default.
- W2019904224 cites W2016237021 @default.
- W2019904224 cites W2017485498 @default.
- W2019904224 cites W2020563114 @default.
- W2019904224 cites W2024233889 @default.
- W2019904224 cites W2025295475 @default.
- W2019904224 cites W2026463427 @default.
- W2019904224 cites W2027490189 @default.
- W2019904224 cites W2029234457 @default.
- W2019904224 cites W2032491383 @default.
- W2019904224 cites W2035445666 @default.
- W2019904224 cites W2038199642 @default.
- W2019904224 cites W2040508887 @default.
- W2019904224 cites W2041280763 @default.
- W2019904224 cites W2041297896 @default.
- W2019904224 cites W2042324713 @default.
- W2019904224 cites W2046312802 @default.
- W2019904224 cites W2047822219 @default.
- W2019904224 cites W2049142446 @default.
- W2019904224 cites W2053409636 @default.
- W2019904224 cites W2061673468 @default.
- W2019904224 cites W2063737523 @default.
- W2019904224 cites W2064984600 @default.
- W2019904224 cites W2066395665 @default.
- W2019904224 cites W2068226038 @default.
- W2019904224 cites W2069312752 @default.
- W2019904224 cites W2071546853 @default.
- W2019904224 cites W2071731516 @default.
- W2019904224 cites W2073877757 @default.
- W2019904224 cites W2075480456 @default.
- W2019904224 cites W2077860496 @default.
- W2019904224 cites W2078542966 @default.
- W2019904224 cites W2081283430 @default.
- W2019904224 cites W2084606714 @default.
- W2019904224 cites W2087748984 @default.
- W2019904224 cites W2090586492 @default.
- W2019904224 cites W2090692926 @default.
- W2019904224 cites W2091553554 @default.
- W2019904224 cites W2094165155 @default.
- W2019904224 cites W2094201715 @default.
- W2019904224 cites W2096768293 @default.
- W2019904224 cites W2097278548 @default.
- W2019904224 cites W2098289285 @default.
- W2019904224 cites W2101879993 @default.
- W2019904224 cites W2104803101 @default.
- W2019904224 cites W2107096576 @default.
- W2019904224 cites W2107658615 @default.
- W2019904224 cites W2110042391 @default.
- W2019904224 cites W2111370401 @default.
- W2019904224 cites W2113892902 @default.
- W2019904224 cites W2114968904 @default.
- W2019904224 cites W2115055938 @default.
- W2019904224 cites W2116594128 @default.
- W2019904224 cites W2118794261 @default.
- W2019904224 cites W2119410661 @default.
- W2019904224 cites W2127379267 @default.
- W2019904224 cites W2129062531 @default.
- W2019904224 cites W2130907702 @default.
- W2019904224 cites W2132079098 @default.
- W2019904224 cites W2136073528 @default.