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- W2019904406 abstract "Chloroquine is a critically important antimalarial drug and a well known intercalator into DNA. We now show that chloroquine binds more avidly to poly(dG-dC)·poly(dG-dC) than to other synthetic polynucleotides and that this binding inhibits both salt- and cobalt-induced transitions to Z-DNA. These data are consistent with the possibility that chloroquine's toxicity to malarial parasites is mediated by its effect on DNA." @default.
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- W2019904406 date "1990-03-01" @default.
- W2019904406 modified "2023-10-11" @default.
- W2019904406 title "Sequence preference of chloroquine binding to DNA and prevention of Z-DNA formation" @default.
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- W2019904406 doi "https://doi.org/10.1016/0166-6851(90)90066-u" @default.
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