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• W2019907846 abstract "Childhood asthma is intimately connected to inhalant allergen sensitization. Although not every child with asthma is allergic, most are.1 The longitudinal study of Melbourne schoolchildren initiated in the 1960s by Williams and McNicol has clearly demonstrated the importance of allergic sensitization in not only the presence of asthma, but also its severity.2 Sears and colleagues came to the same conclusion in follow-up of the Dunedin birth cohort, in that prevalence of asthma was highly correlated with level of total serum immunoglobulin E (IgE)3 as well as sensitization to cat allergen.4 A classic study by Sporik and colleagues5 demonstrated that exposure to high levels of dust mite (>10 μg Der p1 /g of dust) during the first 2 years of life increased the risk of developing asthma 4.8-fold in a cohort of children at risk due to having at least 1 parent with asthma or hay fever.Numerous studies have demonstrated the effects of inhalant allergen exposure on asthma severity. Exposure and allergic sensitization to cockroach was associated with significantly greater risk of asthma hospitalization and greater health care utilization among 476 children aged 4 to 9 years who participated in the National Cooperative Inner-City Asthma Study.6 Allergic sensitization to the mold Alternaria has been identified associated with increasing airway hyperresponsiveness among schoolchildren,7 as well as with a nearly 200-fold increased risk of respiratory arrest attributable to asthma.8 The Childhood Asthma Management Program (CAMP), comprised of 1041 children aged 5 to 12 with mild to moderate asthma, found that allergic sensitization to tree pollen, weed pollen, Alternaria , cat dander, dog dander, or indoor molds was associated with greater airway hyperresponsiveness to methacholine.1 In CAMP patients, nocturnal awakening was strongly associated with allergy to environmental allergens.9Pet allergy is particularly important …" @default.
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• W2019907846 date "2003-10-01" @default.
• W2019907846 modified "2023-09-28" @default.
• W2019907846 title "Pets and Childhood Asthma--How Should the Pediatrician Respond to New Information That Pets May Prevent Asthma?" @default.
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• W2019907846 doi "https://doi.org/10.1542/peds.112.4.974" @default.
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