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- W2019907883 abstract "The spindle midzone is critical for spindle stability and cytokinesis. Chromosomal passenger proteins relocalize from chromosomes to the spindle midzone after anaphase onset. The recent localization of the inner-kinetochore, centromere-binding factor 3 (CBF3) complex to the spindle midzone in budding yeast has led to the discovery of novel functions for this complex in addition to its essential role at kinetochores. In G1/S cells, CBF3 components are detected along dynamic microtubules, where they can search-and-capture newly replicated centromeres. During anaphase, CBF3 is transported to the microtubule plus-ends of the spindle midzone. Consistent with this localization, cells containing a mutation in the CBF3 subunit Ndc10p show defects in spindle stability during anaphase. In addition, ndc10-1 cells show defects during cytokinesis, resulting in a defect in cell abscission. These results highlight the importance of midzone-targeted proteins in coordinating mitosis with cell division. Here we discuss these findings and explore the significance of CBF3 transport to microtubule plus-ends at the spindle midzone.Key words: spindle midzone, passenger protein, inner centromere protein (INCENP), microtubule plus-end." @default.
- W2019907883 created "2016-06-24" @default.
- W2019907883 creator A5068057210 @default.
- W2019907883 creator A5087910135 @default.
- W2019907883 date "2005-12-01" @default.
- W2019907883 modified "2023-10-17" @default.
- W2019907883 title "The role of centromere-binding factor 3 (CBF3) in spindle stability, cytokinesis, and kinetochore attachment" @default.
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- W2019907883 doi "https://doi.org/10.1139/o05-161" @default.
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