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- W2019908045 abstract "In the present study the effects of intracerebroventricularly [icv] administered somatostatin [linear and cyclic], somatostatin3-6, somatostatin7-10 and des AA1,2,4,5,12,13 [D-Trp8] somatostatin [ODT8-SS] were investigated on electroconvulsive shock [ECS]-induced retrograde amnesia in rats. The ECS significantly decreased the foot shock-induced avoidance latency, and thus caused retrograde amnesia. Somatostatin [linear and cyclic] in a dose of 0.6 nM had no action on the ECS-induced retrograde amnesia, while in doses of 3 nM and [cyclic only] 6 nM it significantly prevented it. Somatostatin3-6, somatostatin7-10 and ODT8-SS in doses of 0.6, 3 and 6 nM had no effect on the ECS-induced amnesia. These results indicate that the whole sequence of the original somatostatin molecule is needed to block the ECS-caused retrograde amnesia." @default.
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- W2019908045 date "1984-03-01" @default.
- W2019908045 modified "2023-09-27" @default.
- W2019908045 title "The effect of somatostatin, its fragments and an analog on electroconvulsive shock-induced amnesia in rats" @default.
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- W2019908045 doi "https://doi.org/10.1016/0143-4179(84)90124-0" @default.
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