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- W2019908115 abstract "Small constrained non-peptidic molecules consisting of a polyfunctionalized rigid core, carrying appendages corresponding to arginine and aspartic acid side chains, have been recently reported to be promising for drug development. In this work, the 5,6-dihydropyridin-2-one was envisaged as a scaffold to turn into potential integrin ligands, introducing a carboxylic acid and a basic appendage. The synthesis and the antiadhesion activity of a small library of peptidomimetics capable to recognize alpha(v)beta(3) and alpha(5)beta(1) integrins has been herein reported." @default.
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- W2019908115 date "2007-12-01" @default.
- W2019908115 modified "2023-10-16" @default.
- W2019908115 title "Synthesis and biological evaluation of non-peptide αvβ3/α5β1 integrin dual antagonists containing 5,6-dihydropyridin-2-one scaffolds" @default.
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- W2019908115 doi "https://doi.org/10.1016/j.bmc.2007.07.049" @default.
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