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- W2019908928 abstract "Abstract The development of adrenocortical hemorrhagic necrosis following treatment with cysteamine was studied in rats. Increased vascular permeability, originating in the inner cortical layers, resulted in congestion, platelet aggregation, edema, and hemorrhage which, over a 12-hr period, spread outward to the capsule. Paralleling these changes, retrograde emboli of medullary cells were found in the capillaries of the zona reticularis and fasciculata. Subsequently, the lesions progressed to hemorrhagic necrosis. Cysteamine-induced adrenocortical necrosis was significantly suppressed by medullectomy, hypophysectomy, treatment with aminoglutethimide, and somatostatin, while it was moderately reduced by phenoxybenzamine, labetatol, and metyrapone. ACTH and propranolol provided no protection. The lesion may develop through a dual pathway: one mediated via release of catecholamines directly into cortical capillaries, while the other may involve the production of toxic metabolite." @default.
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- W2019908928 date "1981-12-01" @default.
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- W2019908928 title "Cysteamine-induced adrenocortical necrosis in rats" @default.
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- W2019908928 doi "https://doi.org/10.1016/0014-4800(81)90025-3" @default.
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