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• W2019909215 abstract "Fibril fragmentation is considered to be an essential step in prion replication. Recent studies have revealed a strong correlation between the incubation period to prion disease and conformational stability of synthetic prions. To gain insight into the molecular mechanism that accounts for this correlation, we proposed that the conformational stability of prion fibrils controls their intrinsic fragility or the size of the smallest possible fibrillar fragments. Using amyloid fibrils produced from full-length mammalian prion protein under three growth conditions, we found a correlation between conformational stability and the smallest possible fragment sizes. Specifically, the fibrils that were conformationally less stable were found to produce shorter pieces upon fragmentation. Site-specific denaturation experiments revealed that the fibril conformational stability was controlled by the region that acquires a cross-β-sheet structure. Using atomic force microscopy imaging, we found that fibril fragmentation occurred in both directions—perpendicular to and along the fibrillar axis. Two mechanisms of fibril fragmentation were identified: (i) fragmentation caused by small heat shock proteins, including αB-crystallin, and (ii) fragmentation due to mechanical stress arising from adhesion of the fibril to a surface. This study provides new mechanistic insight into the prion replication mechanism and offers a plausible explanation for the correlation between conformational stability of synthetic prions and incubation time to prion disease." @default.
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• W2019909215 date "2008-02-01" @default.
• W2019909215 modified "2023-09-24" @default.
• W2019909215 title "Conformational Stability of PrP Amyloid Fibrils Controls Their Smallest Possible Fragment Size" @default.
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• W2019909215 doi "https://doi.org/10.1016/j.jmb.2007.12.053" @default.
• W2019909215 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2276463" @default.
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