FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019909260> ?p ?o ?g. }

• W2019909260 endingPage "1308" @default.
• W2019909260 startingPage "1302" @default.
• W2019909260 abstract "PurposeThe aim of this cross-sectional study was to investigate concentrations of cartilage and bone markers, and pro-inflammatory cytokines in synovial fluid (SF) collected at different time-points from acutely injured knees with hemarthrosis and to compare these with SF concentrations of knees of age and gender-matched healthy reference subjects.MethodsSF was aspirated from the acutely injured knee of 111 individuals (mean age 27 years, span 13–64 years, 22% women). Concentrations of sulfated glycosaminoglycan (sGAG) were measured by Alcian blue precipitation whereas cartilage ARGS, bone biomarkers [osteocalcin (OCL), secreted protein acidic and rich in cysteine (SPARC) and osteopontin (OPN)] and pro-inflammatory cytokines [interleukin (IL)-1β, IL-6, IL-8 and tumor necrosis factor (TNF)-α] were analyzed using electrochemiluminescence. Samples were also analyzed with regard to time between injury and aspiration [same day (n = 29), 1 day (n = 31), 2–3 days (n = 19), 4–7 days (n = 20) and 8–23 days (n = 12)].ResultsSF concentrations of ARGS (P < 0.001), SPARC (P < 0.001), OPN (P < 0.001), and all cytokines (P < 0.001), but not sGAG (P = 0.06) or OCL (P = 0.992), were significantly higher in injured knees compared to knees of reference subjects. The cartilage markers sGAG and ARGS were significantly higher in knees aspirated later than 1 day after injury, whereas concentrations of SPARC and OPN and all cytokines were higher in knees aspirated the same day as the injury and at all time-points thereafter.ConclusionsOur results suggest that an acute knee injury is associated with an instant local biochemical response to the trauma, which may affect cartilage and bone as well as the inflammatory activity. The aim of this cross-sectional study was to investigate concentrations of cartilage and bone markers, and pro-inflammatory cytokines in synovial fluid (SF) collected at different time-points from acutely injured knees with hemarthrosis and to compare these with SF concentrations of knees of age and gender-matched healthy reference subjects. SF was aspirated from the acutely injured knee of 111 individuals (mean age 27 years, span 13–64 years, 22% women). Concentrations of sulfated glycosaminoglycan (sGAG) were measured by Alcian blue precipitation whereas cartilage ARGS, bone biomarkers [osteocalcin (OCL), secreted protein acidic and rich in cysteine (SPARC) and osteopontin (OPN)] and pro-inflammatory cytokines [interleukin (IL)-1β, IL-6, IL-8 and tumor necrosis factor (TNF)-α] were analyzed using electrochemiluminescence. Samples were also analyzed with regard to time between injury and aspiration [same day (n = 29), 1 day (n = 31), 2–3 days (n = 19), 4–7 days (n = 20) and 8–23 days (n = 12)]. SF concentrations of ARGS (P < 0.001), SPARC (P < 0.001), OPN (P < 0.001), and all cytokines (P < 0.001), but not sGAG (P = 0.06) or OCL (P = 0.992), were significantly higher in injured knees compared to knees of reference subjects. The cartilage markers sGAG and ARGS were significantly higher in knees aspirated later than 1 day after injury, whereas concentrations of SPARC and OPN and all cytokines were higher in knees aspirated the same day as the injury and at all time-points thereafter. Our results suggest that an acute knee injury is associated with an instant local biochemical response to the trauma, which may affect cartilage and bone as well as the inflammatory activity." @default.
• W2019909260 created "2016-06-24" @default.
• W2019909260 creator A5007044951 @default.
• W2019909260 creator A5038053416 @default.
• W2019909260 creator A5038430565 @default.
• W2019909260 creator A5075058156 @default.
• W2019909260 creator A5090242065 @default.
• W2019909260 date "2012-11-01" @default.
• W2019909260 modified "2023-10-18" @default.
• W2019909260 title "Cartilage and bone markers and inflammatory cytokines are increased in synovial fluid in the acute phase of knee injury (hemarthrosis) – a cross-sectional analysis" @default.
• W2019909260 cites W1584352251 @default.
• W2019909260 cites W1975459324 @default.
• W2019909260 cites W1983005165 @default.
• W2019909260 cites W1993990835 @default.
• W2019909260 cites W2000996628 @default.
• W2019909260 cites W2001958765 @default.
• W2019909260 cites W2010294534 @default.
• W2019909260 cites W2013322971 @default.
• W2019909260 cites W2014277609 @default.
• W2019909260 cites W2015769931 @default.
• W2019909260 cites W2021438355 @default.
• W2019909260 cites W2032752377 @default.
• W2019909260 cites W2041233125 @default.
• W2019909260 cites W2041287210 @default.
• W2019909260 cites W2042796912 @default.
• W2019909260 cites W2046861848 @default.
• W2019909260 cites W2054500578 @default.
• W2019909260 cites W2064110564 @default.
• W2019909260 cites W2065576866 @default.
• W2019909260 cites W2067973973 @default.
• W2019909260 cites W2072563625 @default.
• W2019909260 cites W2077679509 @default.
• W2019909260 cites W2081204360 @default.
• W2019909260 cites W2090482130 @default.
• W2019909260 cites W2095662471 @default.
• W2019909260 cites W2111228339 @default.
• W2019909260 cites W2114560977 @default.
• W2019909260 cites W2114676488 @default.
• W2019909260 cites W2117062936 @default.
• W2019909260 cites W2118963985 @default.
• W2019909260 cites W2119834899 @default.
• W2019909260 cites W2122751744 @default.
• W2019909260 cites W2137713258 @default.
• W2019909260 cites W2143461769 @default.
• W2019909260 cites W2151528581 @default.
• W2019909260 cites W2163757047 @default.
• W2019909260 doi "https://doi.org/10.1016/j.joca.2012.07.021" @default.
• W2019909260 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22874525" @default.
• W2019909260 hasPublicationYear "2012" @default.
• W2019909260 type Work @default.
• W2019909260 sameAs 2019909260 @default.
• W2019909260 citedByCount "130" @default.
• W2019909260 countsByYear W20199092602013 @default.
• W2019909260 countsByYear W20199092602014 @default.
• W2019909260 countsByYear W20199092602015 @default.
• W2019909260 countsByYear W20199092602016 @default.
• W2019909260 countsByYear W20199092602017 @default.
• W2019909260 countsByYear W20199092602018 @default.
• W2019909260 countsByYear W20199092602019 @default.
• W2019909260 countsByYear W20199092602020 @default.
• W2019909260 countsByYear W20199092602021 @default.
• W2019909260 countsByYear W20199092602022 @default.
• W2019909260 countsByYear W20199092602023 @default.
• W2019909260 crossrefType "journal-article" @default.
• W2019909260 hasAuthorship W2019909260A5007044951 @default.
• W2019909260 hasAuthorship W2019909260A5038053416 @default.
• W2019909260 hasAuthorship W2019909260A5038430565 @default.
• W2019909260 hasAuthorship W2019909260A5075058156 @default.
• W2019909260 hasAuthorship W2019909260A5090242065 @default.
• W2019909260 hasBestOaLocation W20199092601 @default.
• W2019909260 hasConcept C105702510 @default.
• W2019909260 hasConcept C11988809 @default.
• W2019909260 hasConcept C126322002 @default.
• W2019909260 hasConcept C131075544 @default.
• W2019909260 hasConcept C141071460 @default.
• W2019909260 hasConcept C142724271 @default.
• W2019909260 hasConcept C153074725 @default.
• W2019909260 hasConcept C160160445 @default.
• W2019909260 hasConcept C164027704 @default.
• W2019909260 hasConcept C17991360 @default.
• W2019909260 hasConcept C181199279 @default.
• W2019909260 hasConcept C185592680 @default.
• W2019909260 hasConcept C204787440 @default.
• W2019909260 hasConcept C2776164576 @default.
• W2019909260 hasConcept C2776268809 @default.
• W2019909260 hasConcept C2776914184 @default.
• W2019909260 hasConcept C2778690821 @default.
• W2019909260 hasConcept C2779526002 @default.
• W2019909260 hasConcept C2780550940 @default.
• W2019909260 hasConcept C2780804394 @default.
• W2019909260 hasConcept C55493867 @default.
• W2019909260 hasConcept C71924100 @default.
• W2019909260 hasConcept C74172505 @default.
• W2019909260 hasConceptScore W2019909260C105702510 @default.
• W2019909260 hasConceptScore W2019909260C11988809 @default.
• W2019909260 hasConceptScore W2019909260C126322002 @default.
• W2019909260 hasConceptScore W2019909260C131075544 @default.
• W2019909260 hasConceptScore W2019909260C141071460 @default.

• next