Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019909669> ?p ?o ?g. }
- W2019909669 endingPage "8531" @default.
- W2019909669 startingPage "8526" @default.
- W2019909669 abstract "Oxidative stress has been implicated in cognitive impairment in both old experimental animals and aged humans. This implication has led to the notion that antioxidant defense mechanisms in the brain are not sufficient to prevent age-related increase in oxidative damage and that dietary intake of a variety of antioxidants might be beneficial for preserving brain function. Here we report a dramatic loss of learning and memory function from 8 to 11 months of age in mice, associated with marked increases in several markers of brain oxidative stress. Chronic systemic administration of two synthetic catalytic scavengers of reactive oxygen species, Eukarion experimental compounds EUK-189 and EUK-207, from 8 to 11 months almost completely reversed cognitive deficits and increase in oxidative stress taking place during this time period in brain. In particular, increase in protein oxidation was completely prevented, whereas increase in lipid peroxidation was decreased by ≈50%. In addition, we observed a significant negative correlation between contextual fear learning and levels of protein oxidation in brain. These results further support the role of reactive oxygen species in age-related learning impairment and suggest potential clinical applications for synthetic catalytic scavengers of reactive oxygen species." @default.
- W2019909669 created "2016-06-24" @default.
- W2019909669 creator A5002938894 @default.
- W2019909669 creator A5009203706 @default.
- W2019909669 creator A5012477004 @default.
- W2019909669 creator A5028020156 @default.
- W2019909669 creator A5033900229 @default.
- W2019909669 creator A5044162854 @default.
- W2019909669 creator A5066748973 @default.
- W2019909669 date "2003-06-18" @default.
- W2019909669 modified "2023-10-14" @default.
- W2019909669 title "Reversal of age-related learning deficits and brain oxidative stress in mice with superoxide dismutase/catalase mimetics" @default.
- W2019909669 cites W1506520614 @default.
- W2019909669 cites W1635887916 @default.
- W2019909669 cites W1964004644 @default.
- W2019909669 cites W1975422962 @default.
- W2019909669 cites W1979894044 @default.
- W2019909669 cites W1980239800 @default.
- W2019909669 cites W1984005657 @default.
- W2019909669 cites W1984541066 @default.
- W2019909669 cites W1992593556 @default.
- W2019909669 cites W1996737152 @default.
- W2019909669 cites W2009688381 @default.
- W2019909669 cites W2019786869 @default.
- W2019909669 cites W2029285462 @default.
- W2019909669 cites W2040833439 @default.
- W2019909669 cites W2042706799 @default.
- W2019909669 cites W2043079388 @default.
- W2019909669 cites W2043109020 @default.
- W2019909669 cites W2046750051 @default.
- W2019909669 cites W2054360287 @default.
- W2019909669 cites W2055912815 @default.
- W2019909669 cites W2056565986 @default.
- W2019909669 cites W2056620406 @default.
- W2019909669 cites W2058807117 @default.
- W2019909669 cites W2087292928 @default.
- W2019909669 cites W2094466584 @default.
- W2019909669 cites W2098430757 @default.
- W2019909669 cites W2113708991 @default.
- W2019909669 cites W2119799206 @default.
- W2019909669 cites W2133557409 @default.
- W2019909669 cites W2139045040 @default.
- W2019909669 cites W2154737719 @default.
- W2019909669 cites W2158553737 @default.
- W2019909669 cites W2166593624 @default.
- W2019909669 cites W2170632631 @default.
- W2019909669 cites W2465766356 @default.
- W2019909669 cites W4243228024 @default.
- W2019909669 cites W4322695843 @default.
- W2019909669 doi "https://doi.org/10.1073/pnas.1332809100" @default.
- W2019909669 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/166262" @default.
- W2019909669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12815103" @default.
- W2019909669 hasPublicationYear "2003" @default.
- W2019909669 type Work @default.
- W2019909669 sameAs 2019909669 @default.
- W2019909669 citedByCount "341" @default.
- W2019909669 countsByYear W20199096692012 @default.
- W2019909669 countsByYear W20199096692013 @default.
- W2019909669 countsByYear W20199096692014 @default.
- W2019909669 countsByYear W20199096692015 @default.
- W2019909669 countsByYear W20199096692016 @default.
- W2019909669 countsByYear W20199096692017 @default.
- W2019909669 countsByYear W20199096692018 @default.
- W2019909669 countsByYear W20199096692019 @default.
- W2019909669 countsByYear W20199096692020 @default.
- W2019909669 countsByYear W20199096692021 @default.
- W2019909669 countsByYear W20199096692022 @default.
- W2019909669 countsByYear W20199096692023 @default.
- W2019909669 crossrefType "journal-article" @default.
- W2019909669 hasAuthorship W2019909669A5002938894 @default.
- W2019909669 hasAuthorship W2019909669A5009203706 @default.
- W2019909669 hasAuthorship W2019909669A5012477004 @default.
- W2019909669 hasAuthorship W2019909669A5028020156 @default.
- W2019909669 hasAuthorship W2019909669A5033900229 @default.
- W2019909669 hasAuthorship W2019909669A5044162854 @default.
- W2019909669 hasAuthorship W2019909669A5066748973 @default.
- W2019909669 hasBestOaLocation W20199096691 @default.
- W2019909669 hasConcept C126322002 @default.
- W2019909669 hasConcept C134018914 @default.
- W2019909669 hasConcept C15744967 @default.
- W2019909669 hasConcept C181199279 @default.
- W2019909669 hasConcept C185592680 @default.
- W2019909669 hasConcept C2775838275 @default.
- W2019909669 hasConcept C2776151105 @default.
- W2019909669 hasConcept C2778004101 @default.
- W2019909669 hasConcept C2778979269 @default.
- W2019909669 hasConcept C2780795997 @default.
- W2019909669 hasConcept C2780829032 @default.
- W2019909669 hasConcept C48349386 @default.
- W2019909669 hasConcept C55493867 @default.
- W2019909669 hasConcept C57600042 @default.
- W2019909669 hasConcept C71924100 @default.
- W2019909669 hasConcept C98274493 @default.
- W2019909669 hasConceptScore W2019909669C126322002 @default.
- W2019909669 hasConceptScore W2019909669C134018914 @default.
- W2019909669 hasConceptScore W2019909669C15744967 @default.
- W2019909669 hasConceptScore W2019909669C181199279 @default.
- W2019909669 hasConceptScore W2019909669C185592680 @default.