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- W2019910485 abstract "There is a substantive literature on the behavioral effects of psychosocial stressors on schizophrenia. More recently, research has been conducted on neurohormonal indicators of stress responsivity, particularly cortisol release resulting from activation of the hypothalamic-pituitary-adrenal (HPA) axis. This article integrates the psychosocial and biological literatures on stress in schizophrenia, and it offers specific hypotheses about the neural mechanisms involved in the effects of stressors on the diathesis. Both the behavioral and biological data indicate that stress worsens symptoms and that the diathesis is associated with a heightened response to stressors. A neural mechanism for these phenomena is suggested by the augmenting effect of the HPA axis on dopamine (DA) synthesis and receptors. Assuming the diathesis for schizophrenia involves an abnormality in DA receptors, it is proposed that the HPA axis acts as a potentiating system by means of its effects on DA. At the same time, DA receptor abnormality and hippocampal damage render the patient hypersensitive to stress. This neural diathesis-stress model is consistent with findings on prenatal factors and brain abnormalities in schizophrenia, and it provides a framework for explaining some key features of the developmental course and clinical presentation." @default.
- W2019910485 created "2016-06-24" @default.
- W2019910485 creator A5037164680 @default.
- W2019910485 creator A5060010092 @default.
- W2019910485 date "1997-01-01" @default.
- W2019910485 modified "2023-10-17" @default.
- W2019910485 title "Schizophrenia: A neural diathesis-stress model." @default.
- W2019910485 cites W123783387 @default.
- W2019910485 cites W1513126258 @default.
- W2019910485 cites W1519712908 @default.
- W2019910485 cites W1524313850 @default.
- W2019910485 cites W1642124290 @default.
- W2019910485 cites W1786000015 @default.
- W2019910485 cites W1898014694 @default.
- W2019910485 cites W1906690582 @default.
- W2019910485 cites W1948643290 @default.
- W2019910485 cites W1948681014 @default.
- W2019910485 cites W1963782790 @default.
- W2019910485 cites W1964695145 @default.
- W2019910485 cites W1965090015 @default.
- W2019910485 cites W1965259361 @default.
- W2019910485 cites W1965502156 @default.
- W2019910485 cites W1966920369 @default.
- W2019910485 cites W1968959126 @default.
- W2019910485 cites W1971422535 @default.
- W2019910485 cites W1971440513 @default.
- W2019910485 cites W1973464479 @default.
- W2019910485 cites W1974010389 @default.
- W2019910485 cites W1975988892 @default.
- W2019910485 cites W1976036739 @default.
- W2019910485 cites W1976667968 @default.
- W2019910485 cites W1977320688 @default.
- W2019910485 cites W1978062231 @default.
- W2019910485 cites W1978823883 @default.
- W2019910485 cites W1979225061 @default.
- W2019910485 cites W1979563389 @default.
- W2019910485 cites W1979791030 @default.
- W2019910485 cites W1981480708 @default.
- W2019910485 cites W1981838182 @default.
- W2019910485 cites W1981917957 @default.
- W2019910485 cites W1982382278 @default.
- W2019910485 cites W1983067648 @default.
- W2019910485 cites W1983340882 @default.
- W2019910485 cites W1983922562 @default.
- W2019910485 cites W1983978905 @default.
- W2019910485 cites W1984427714 @default.
- W2019910485 cites W1984992253 @default.
- W2019910485 cites W1986218232 @default.
- W2019910485 cites W1986981219 @default.
- W2019910485 cites W1987177354 @default.
- W2019910485 cites W1989668666 @default.
- W2019910485 cites W1990294572 @default.
- W2019910485 cites W1990792290 @default.
- W2019910485 cites W1993206740 @default.
- W2019910485 cites W1993761786 @default.
- W2019910485 cites W1994137116 @default.
- W2019910485 cites W1995308040 @default.
- W2019910485 cites W1995362640 @default.
- W2019910485 cites W1997466305 @default.
- W2019910485 cites W1998700474 @default.
- W2019910485 cites W2002040445 @default.
- W2019910485 cites W2003759197 @default.
- W2019910485 cites W2006770638 @default.
- W2019910485 cites W2007253085 @default.
- W2019910485 cites W2007990596 @default.
- W2019910485 cites W2008378372 @default.
- W2019910485 cites W2008450195 @default.
- W2019910485 cites W2008830365 @default.
- W2019910485 cites W2009737184 @default.
- W2019910485 cites W2010584142 @default.
- W2019910485 cites W201083129 @default.
- W2019910485 cites W2011180659 @default.
- W2019910485 cites W2012245779 @default.
- W2019910485 cites W2014735291 @default.
- W2019910485 cites W2015087721 @default.
- W2019910485 cites W2015908820 @default.
- W2019910485 cites W2017580158 @default.
- W2019910485 cites W2018195755 @default.
- W2019910485 cites W2019144775 @default.
- W2019910485 cites W2020384208 @default.
- W2019910485 cites W2020627096 @default.
- W2019910485 cites W2021398755 @default.
- W2019910485 cites W2021474867 @default.
- W2019910485 cites W2022716807 @default.
- W2019910485 cites W2023298760 @default.
- W2019910485 cites W2025591610 @default.
- W2019910485 cites W2025795611 @default.
- W2019910485 cites W2027066838 @default.
- W2019910485 cites W2027985523 @default.
- W2019910485 cites W2028884770 @default.
- W2019910485 cites W2028950009 @default.
- W2019910485 cites W2029625160 @default.
- W2019910485 cites W2030780031 @default.
- W2019910485 cites W2035285871 @default.
- W2019910485 cites W2036115706 @default.
- W2019910485 cites W2036955070 @default.
- W2019910485 cites W2038388311 @default.
- W2019910485 cites W2042709208 @default.