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- W2019910617 abstract "Patients suffering from neuropsychiatric disorders often exhibit a loss of regulation of their biological rhythms which leads to altered sleep/wake cycle, body temperature rhythm and hormonal rhythms. Whereas these symptoms have long been considered to result from the pathology of the underlying disease, increasing evidence now indicates that the circadian system may be more directly involved in the etiology of psychiatric disorders. This emerging view originated with the discovery that the genes involved in the generation of biological rhythms are expressed in many brain structures where clocks function-and perhaps malfunction. It is also due to the interesting phenotypes of clock mutant mice. Here we summarize recent reports showing that alteration of circadian clocks within key brain regions associated with neuropsychiatric disorders may be an underlying cause of the development of mental illness. We discuss how these alterations take place at both systems and molecular levels." @default.
- W2019910617 created "2016-06-24" @default.
- W2019910617 creator A5014720670 @default.
- W2019910617 creator A5068402917 @default.
- W2019910617 date "2011-12-01" @default.
- W2019910617 modified "2023-10-17" @default.
- W2019910617 title "When brain clocks lose track of time: cause or consequence of neuropsychiatric disorders" @default.
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- W2019910617 doi "https://doi.org/10.1016/j.conb.2011.06.008" @default.
- W2019910617 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3252427" @default.
- W2019910617 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21737252" @default.
- W2019910617 hasPublicationYear "2011" @default.
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