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- W2019910836 abstract "The major challenge to the field in studies of osteoarthritis (OA) and degenerative disc disease (DDD) is currently to understand how signs and symptoms of disease relate to structural damage. Cartilage degradation is a favored target for therapeutic intervention, but the development of new therapies has been hampered because it is difficult to assess the efficacy of structure-modifying drugs if they do not modify pain perception. Pain is the most prominent but least well studied feature of OA and DDD. Although the normal joint may respond predictably to painful stimuli, there is often a poor correlation between the perceived pain in chronic arthritis and the structural damage assessed radiographically. Developing models for assessing the pathological factors and mechanisms responsible for joint pain in OA has been difficult because of the subjective nature of pain and the complex role of cognitive interpretation of sensory information." @default.
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- W2019910836 date "2009-09-01" @default.
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- W2019910836 title "The link between structural damage and pain in a genetic model of osteoarthritis and intervertebral disc degeneration: A joint misadventure" @default.
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- W2019910836 doi "https://doi.org/10.1002/art.24771" @default.
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