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- W2019911027 endingPage "2485" @default.
- W2019911027 startingPage "2465" @default.
- W2019911027 abstract "The pituitary gonadotropin hormones, FSH and LH, are key regulators of reproductive physiology. Though the two hormones are produced by the same cell type, often in response to the same endocrine and paracrine regulators, they sub-serve different biological functions and their synthesis and secretion are differentially regulated. This stems largely from differences in transcriptional, post-transcriptional, and post-translational regulation of their unique beta subunits. That is, both hormones are dimeric glycoproteins and share a common alpha subunit. Their unique beta subunits, however, derive from different genes encoding distinct proteins. Past and recent research indicates synthesis and release of the two hormones are subject to extensive and independent regulation. LH appears to be secreted predominantly via the regulated secretory pathway, whereas FSH release is largely constitutive. As such, investigations of FSH-beta subunit synthesis may lend direct insight into mechanisms underlying patterns of secreted FSH, more so than investigations of the LHbeta subunit. Here, we review recent investigations of transcriptional regulation of the FSH-beta subunit gene from different mammalian species, including humans. The results reveal both conserved and species-specific regulatory mechanisms that might contribute to inter-species variation in FSH release." @default.
- W2019911027 created "2016-06-24" @default.
- W2019911027 creator A5018863416 @default.
- W2019911027 creator A5060573622 @default.
- W2019911027 creator A5081262584 @default.
- W2019911027 creator A5088026877 @default.
- W2019911027 date "2010-05-01" @default.
- W2019911027 modified "2023-10-16" @default.
- W2019911027 title "Mechanisms of FSH synthesis: what we know, what we don't, and why you should care" @default.
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