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- W2019911166 abstract "Abstract The carcinogenicity of vinyl bromide was evaluated during an inhalation study in which Sprague-Dawley rats were exposed for 6 hr daily, 5 days per week for 2 years, in 6-m3 stainless steel and glass inhalation chambers. The four exposure levels to vinyl bromide in air were 9.7, 52, 247, and 1235 ppm. The controls were exposed to filtered and conditioned outside air. Moribund rats and rats in groups scheduled for termination from the control and exposed levels following 6, 12, 18, and 24 months of exposure were necropsied and examined for histopathologic changes. Body weights, mortality, hematology, urinalysis, clinical chemistry, terminal organ weights, histopathology, and analytical observations were conducted. A decline in body weights was evident among all exposure levels. Microcytic anemia, elevated serum bromide levels, decreased BUN, elevated alkaline phosphatase, elevated LDH, and hematuria were observed. Angiosarcomas, primarily of the liver, were induced in both male and female rats in all four exposure groups. An increase in the number of Zymbal's gland neoplasms was found in both male and female rats at 52-, 247-, and 1235-ppm exposure levels. An increased incidence of primary hepatocellular neoplasms was seen in males exposed to 247 ppm and in females exposed to 9.7, 52, and 247 ppm. The increase in primary hepatocellular neoplasms was detected primarily in animals that survived the 24-month exposure or died following 18 months of exposure. No exposure-related pathology was observed in the brains of the rats." @default.
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- W2019911166 date "1982-07-01" @default.
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- W2019911166 title "Inhalation carcinogenicity bioassay of vinyl bromide in rats" @default.
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- W2019911166 doi "https://doi.org/10.1016/0041-008x(82)90233-2" @default.
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