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• W2019911223 endingPage "e1003489" @default.
• W2019911223 startingPage "e1003489" @default.
• W2019911223 abstract "A venerable history of classical work on autoassociative memory has significantly shaped our understanding of several features of the hippocampus, and most prominently of its CA3 area, in relation to memory storage and retrieval. However, existing theories of hippocampal memory processing ignore a key biological constraint affecting memory storage in neural circuits: the bounded dynamical range of synapses. Recent treatments based on the notion of metaplasticity provide a powerful model for individual bounded synapses; however, their implications for the ability of the hippocampus to retrieve memories well and the dynamics of neurons associated with that retrieval are both unknown. Here, we develop a theoretical framework for memory storage and recall with bounded synapses. We formulate the recall of a previously stored pattern from a noisy recall cue and limited-capacity (and therefore lossy) synapses as a probabilistic inference problem, and derive neural dynamics that implement approximate inference algorithms to solve this problem efficiently. In particular, for binary synapses with metaplastic states, we demonstrate for the first time that memories can be efficiently read out with biologically plausible network dynamics that are completely constrained by the synaptic plasticity rule, and the statistics of the stored patterns and of the recall cue. Our theory organises into a coherent framework a wide range of existing data about the regulation of excitability, feedback inhibition, and network oscillations in area CA3, and makes novel and directly testable predictions that can guide future experiments." @default.
• W2019911223 created "2016-06-24" @default.
• W2019911223 creator A5001112461 @default.
• W2019911223 creator A5023602087 @default.
• W2019911223 creator A5075063030 @default.
• W2019911223 date "2014-02-27" @default.
• W2019911223 modified "2023-10-16" @default.
• W2019911223 title "Optimal Recall from Bounded Metaplastic Synapses: Predicting Functional Adaptations in Hippocampal Area CA3" @default.
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• W2019911223 doi "https://doi.org/10.1371/journal.pcbi.1003489" @default.
• W2019911223 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3937414" @default.
• W2019911223 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24586137" @default.
• W2019911223 hasPublicationYear "2014" @default.
• W2019911223 type Work @default.

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