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• W2019911316 abstract "To investigate the gene expression profile changes in the cerebral cortex of mice injected icv with amyloid beta-protein (Aβ) fragment 25-35 using cDNA microarray. Balb/c mice were randomly divided into a control group and Aβ-treated group. The Morris water maze test was performed to detect the peffect of Aβ-injection on the learning and memory of mice. Atlas Mouse 1.2 Expression Arrays containing 1176 genes were used to investigate the gene expression pattern of each group. The gene expression profiles showed that 19 genes including TBX1, NF-κB, AP-1/c-Jun, cadherin, integrin, erb-B2, and FGFR1 were up-regulated after 2 weeks of icv administration of Aβ; while 12 genes were down-regulated, including NGF, glucose phosphate isomerase 1, AT motif binding factor 1, Na+/K+-ATPase, and Akt. The results provide important leads for pursuing a more complete understanding of the molecular events of Aβ-injection into mice with Alzheimer disease." @default.
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• W2019911316 date "2005-06-01" @default.
• W2019911316 modified "2023-10-18" @default.
• W2019911316 title "Gene expression profile of amyloid beta protein-injected mouse model for Alzheimer disease" @default.
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• W2019911316 doi "https://doi.org/10.1111/j.1745-7254.2005.00129.x" @default.
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