Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019911667> ?p ?o ?g. }
- W2019911667 endingPage "833" @default.
- W2019911667 startingPage "827" @default.
- W2019911667 abstract "Seasonal rhythms of body weight, reflecting altered food intake, energy storage and expenditure, are a common feature of mammals inhabiting temperate and arctic latitudes. They have evolved so that predictable annual changes in the external environment can be anticipated and animals can adjust their physiology and behaviour in preparation for the changing demands of the seasons. These long‐term changes in energy balance are not simply effected by the brain centres and peptidergic pathways known to underlie short‐term homeostatic regulation. Screens of altered gene expression in Siberian hamsters comparing the anabolic summer state in long photoperiods and the catabolic ‘winter’ state in short photoperiods have identified differential gene expression in the hypothalamus. The majority of gene expression changes are confined to two restricted areas: the dorsomedial posterior arcuate nucleus, and the ventral ependymal layer of the third ventricle. Functions encoded by these ‘seasonal’ genes include thyroid hormone metabolism, retinoic acid and histaminergic signalling, and VGF and secretogranin production. The changes in thyroid hormone availability that are brought about by differential activity of deiodinase enzymes are of particular importance because experimental manipulation of central thyroid levels can prevent seasonal cyclicity. Given the importance of thyroid hormone in the initial development of the brain, we hypothesise that thyroid hormone‐dependent plasticity of hypothalamic connections and neurogenesis underlie seasonal cycles of food intake and body weight." @default.
- W2019911667 created "2016-06-24" @default.
- W2019911667 creator A5060226730 @default.
- W2019911667 creator A5074280752 @default.
- W2019911667 date "2008-06-01" @default.
- W2019911667 modified "2023-10-15" @default.
- W2019911667 title "The Regulation of Seasonal Changes in Food Intake and Body Weight" @default.
- W2019911667 cites W1481897226 @default.
- W2019911667 cites W1497258232 @default.
- W2019911667 cites W1528038344 @default.
- W2019911667 cites W1529727688 @default.
- W2019911667 cites W1594976448 @default.
- W2019911667 cites W1895744510 @default.
- W2019911667 cites W1966688432 @default.
- W2019911667 cites W1975045515 @default.
- W2019911667 cites W1979030149 @default.
- W2019911667 cites W1984995591 @default.
- W2019911667 cites W1988377203 @default.
- W2019911667 cites W1989642979 @default.
- W2019911667 cites W1994837965 @default.
- W2019911667 cites W1996713062 @default.
- W2019911667 cites W1997494318 @default.
- W2019911667 cites W2000547255 @default.
- W2019911667 cites W2008516083 @default.
- W2019911667 cites W2013291672 @default.
- W2019911667 cites W2016555592 @default.
- W2019911667 cites W2022181126 @default.
- W2019911667 cites W2022628868 @default.
- W2019911667 cites W2022940644 @default.
- W2019911667 cites W2024987883 @default.
- W2019911667 cites W2025474975 @default.
- W2019911667 cites W2039559366 @default.
- W2019911667 cites W2046683785 @default.
- W2019911667 cites W2048826485 @default.
- W2019911667 cites W2051145715 @default.
- W2019911667 cites W2057635787 @default.
- W2019911667 cites W2060978548 @default.
- W2019911667 cites W2067342827 @default.
- W2019911667 cites W2071307547 @default.
- W2019911667 cites W2076165835 @default.
- W2019911667 cites W2082696833 @default.
- W2019911667 cites W2083250868 @default.
- W2019911667 cites W2084124756 @default.
- W2019911667 cites W2087250763 @default.
- W2019911667 cites W2110110130 @default.
- W2019911667 cites W2118182233 @default.
- W2019911667 cites W2125805001 @default.
- W2019911667 cites W2128112362 @default.
- W2019911667 cites W2149140809 @default.
- W2019911667 cites W2160263770 @default.
- W2019911667 cites W2163658484 @default.
- W2019911667 cites W2903905960 @default.
- W2019911667 cites W4234807830 @default.
- W2019911667 cites W4247166190 @default.
- W2019911667 cites W4249202707 @default.
- W2019911667 cites W4251804473 @default.
- W2019911667 doi "https://doi.org/10.1111/j.1365-2826.2008.01721.x" @default.
- W2019911667 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18601706" @default.
- W2019911667 hasPublicationYear "2008" @default.
- W2019911667 type Work @default.
- W2019911667 sameAs 2019911667 @default.
- W2019911667 citedByCount "112" @default.
- W2019911667 countsByYear W20199116672012 @default.
- W2019911667 countsByYear W20199116672013 @default.
- W2019911667 countsByYear W20199116672014 @default.
- W2019911667 countsByYear W20199116672015 @default.
- W2019911667 countsByYear W20199116672016 @default.
- W2019911667 countsByYear W20199116672017 @default.
- W2019911667 countsByYear W20199116672018 @default.
- W2019911667 countsByYear W20199116672019 @default.
- W2019911667 countsByYear W20199116672020 @default.
- W2019911667 countsByYear W20199116672021 @default.
- W2019911667 countsByYear W20199116672022 @default.
- W2019911667 countsByYear W20199116672023 @default.
- W2019911667 crossrefType "journal-article" @default.
- W2019911667 hasAuthorship W2019911667A5060226730 @default.
- W2019911667 hasAuthorship W2019911667A5074280752 @default.
- W2019911667 hasBestOaLocation W20199116671 @default.
- W2019911667 hasConcept C104745856 @default.
- W2019911667 hasConcept C118303440 @default.
- W2019911667 hasConcept C126322002 @default.
- W2019911667 hasConcept C134018914 @default.
- W2019911667 hasConcept C170493617 @default.
- W2019911667 hasConcept C2491326 @default.
- W2019911667 hasConcept C2777003273 @default.
- W2019911667 hasConcept C2777205416 @default.
- W2019911667 hasConcept C2778288131 @default.
- W2019911667 hasConcept C2778417266 @default.
- W2019911667 hasConcept C2778458369 @default.
- W2019911667 hasConcept C511355011 @default.
- W2019911667 hasConcept C526584372 @default.
- W2019911667 hasConcept C71315377 @default.
- W2019911667 hasConcept C71924100 @default.
- W2019911667 hasConcept C86803240 @default.
- W2019911667 hasConcept C93984277 @default.
- W2019911667 hasConceptScore W2019911667C104745856 @default.
- W2019911667 hasConceptScore W2019911667C118303440 @default.
- W2019911667 hasConceptScore W2019911667C126322002 @default.