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- W2019911914 abstract "Approximately 50% of Wistar “BB” rats spontaneously develop overt diabetes mellitus characterized by loss of β-cells and “insulitis.” To define abnormalities of immunoregulation in these rats, we quantitated their major circulating lymphocyte subsets. Independent of the development of diabetes, we found the BB rats to have a markedly increased percentage of circulating B lymphocytes which is secondary to a severe T-cell lymphocytopenia, with the major circulating T-cell subset reacting with monoclonal antibody W3/25 markedlydecreased. This lymphocytopenia is present in every animal studied and contrasted with studies of the nondiabetic Wistar strain from which the “BB” rats were developed." @default.
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- W2019911914 date "1981-10-01" @default.
- W2019911914 modified "2023-10-03" @default.
- W2019911914 title "The BB Diabetic Rat: Profound T-Cell Lymphocytopenia" @default.
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- W2019911914 doi "https://doi.org/10.2337/diab.30.10.887" @default.
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