FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019912196> ?p ?o ?g. }

• W2019912196 endingPage "360" @default.
• W2019912196 startingPage "347" @default.
• W2019912196 abstract "Most human pyelonephritis Escherichia coli isolates express both mannose (MS)- and globoside (Gal-Gal)-binding pili. An ascending E. coli urinary tract infection model was established in the 16-wk-old female BALB/c mouse to compare the pathogenic significance of MS and Gal-Gal pili and their efficacy as vaccines for the prevention of pyelonephritis. The distribution and density of pilus receptor compounds in urogenital tissues and as soluble compounds in urine were determined with antibodies to the synthetic receptor analogues, alpha D-Gal(1----4) beta D-Gal and alpha D-Man(1----2) alpha D-Man. Both carbohydrates were detected in vagina, bladder, ureter, and renal pelvis epithelium and in collecting duct and tubular cells. A pilus receptor compound also was detected in urine. It competitively inhibited the binding capacity of MS pili and was found to be physically, chemically, and immunologically related to Tamm-Horsfall uromucoid. Infectivity and invasiveness were quantitatively and histologically characterized for four E. coli strains: J96, a human pyelonephritis strain that expresses both MS and Gal-Gal pili; two recombinant strains prepared from J96 chromosomal DNA encoding MS pili or Gal-Gal pili; and the nonpiliated K12 recipient. Intravesicular administration of J96 (10(6) colony-forming units [CFU]) resulted in renal colonization and invasion in each of nine mice. The Gal-Gal clone (10(6) CFU) colonized the kidneys in each of 10 mice but did not invade. In contrast, the MS clone (10(6) CFU) did not colonize renal epithelium or invade. This effect was superceded when larger doses (greater than or equal to 10(10) CFU) of the MS clone were administered in volumes that cause acute vesicoureteric reflux. The efficacy was determined of vaccines composed of pure MS or Gal-Gal pili or the lipopolysaccharide containing O somatic antigen of the challenge strain, J96. The Gal-Gal pilus vaccine blocked renal colonization in 19 of 22 mice and renal invasion in 10 of 11 mice. Gal-Gal pili may be useful immunogens for the prevention of pyelonephritis in anatomically normal urinary tracts." @default.
• W2019912196 created "2016-06-24" @default.
• W2019912196 creator A5010248908 @default.
• W2019912196 creator A5032402763 @default.
• W2019912196 creator A5048621921 @default.
• W2019912196 creator A5066057569 @default.
• W2019912196 date "1985-02-01" @default.
• W2019912196 modified "2023-10-16" @default.
• W2019912196 title "Molecular basis of Escherichia coli colonization of the upper urinary tract in BALB/c mice. Gal-Gal pili immunization prevents Escherichia coli pyelonephritis in the BALB/c mouse model of human pyelonephritis." @default.
• W2019912196 cites W1604658223 @default.
• W2019912196 cites W1762825828 @default.
• W2019912196 cites W1775749144 @default.
• W2019912196 cites W1874425457 @default.
• W2019912196 cites W1880678809 @default.
• W2019912196 cites W1904058845 @default.
• W2019912196 cites W1904553924 @default.
• W2019912196 cites W1904576076 @default.
• W2019912196 cites W1921242279 @default.
• W2019912196 cites W1949443054 @default.
• W2019912196 cites W1970642788 @default.
• W2019912196 cites W1985782125 @default.
• W2019912196 cites W1992252477 @default.
• W2019912196 cites W2006085652 @default.
• W2019912196 cites W2012951648 @default.
• W2019912196 cites W2016113408 @default.
• W2019912196 cites W2016613716 @default.
• W2019912196 cites W2017953077 @default.
• W2019912196 cites W2018289835 @default.
• W2019912196 cites W2024007545 @default.
• W2019912196 cites W2032408353 @default.
• W2019912196 cites W2045552068 @default.
• W2019912196 cites W2056729760 @default.
• W2019912196 cites W2072424528 @default.
• W2019912196 cites W2078128192 @default.
• W2019912196 cites W2095324682 @default.
• W2019912196 cites W2095742095 @default.
• W2019912196 cites W2100837269 @default.
• W2019912196 cites W2101108802 @default.
• W2019912196 cites W2117190793 @default.
• W2019912196 cites W2119460480 @default.
• W2019912196 cites W2124941807 @default.
• W2019912196 cites W2129400052 @default.
• W2019912196 cites W2133736504 @default.
• W2019912196 cites W2144498842 @default.
• W2019912196 cites W2158175350 @default.
• W2019912196 cites W2162882099 @default.
• W2019912196 cites W2164575111 @default.
• W2019912196 cites W2166582167 @default.
• W2019912196 cites W2171818129 @default.
• W2019912196 cites W2265067966 @default.
• W2019912196 cites W2319685485 @default.
• W2019912196 cites W2346288906 @default.
• W2019912196 cites W2404156592 @default.
• W2019912196 cites W2414708343 @default.
• W2019912196 cites W2467108809 @default.
• W2019912196 doi "https://doi.org/10.1172/jci111707" @default.
• W2019912196 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/423490" @default.
• W2019912196 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2857730" @default.
• W2019912196 hasPublicationYear "1985" @default.
• W2019912196 type Work @default.
• W2019912196 sameAs 2019912196 @default.
• W2019912196 citedByCount "212" @default.
• W2019912196 countsByYear W20199121962012 @default.
• W2019912196 countsByYear W20199121962013 @default.
• W2019912196 countsByYear W20199121962014 @default.
• W2019912196 countsByYear W20199121962015 @default.
• W2019912196 countsByYear W20199121962016 @default.
• W2019912196 countsByYear W20199121962017 @default.
• W2019912196 countsByYear W20199121962018 @default.
• W2019912196 countsByYear W20199121962019 @default.
• W2019912196 countsByYear W20199121962020 @default.
• W2019912196 countsByYear W20199121962021 @default.
• W2019912196 countsByYear W20199121962022 @default.
• W2019912196 crossrefType "journal-article" @default.
• W2019912196 hasAuthorship W2019912196A5010248908 @default.
• W2019912196 hasAuthorship W2019912196A5032402763 @default.
• W2019912196 hasAuthorship W2019912196A5048621921 @default.
• W2019912196 hasAuthorship W2019912196A5066057569 @default.
• W2019912196 hasBestOaLocation W20199121961 @default.
• W2019912196 hasConcept C104317684 @default.
• W2019912196 hasConcept C153911025 @default.
• W2019912196 hasConcept C174832134 @default.
• W2019912196 hasConcept C2778910516 @default.
• W2019912196 hasConcept C2780026642 @default.
• W2019912196 hasConcept C2910768159 @default.
• W2019912196 hasConcept C39103817 @default.
• W2019912196 hasConcept C547475151 @default.
• W2019912196 hasConcept C55493867 @default.
• W2019912196 hasConcept C74460091 @default.
• W2019912196 hasConcept C81089528 @default.
• W2019912196 hasConcept C86803240 @default.
• W2019912196 hasConcept C89423630 @default.
• W2019912196 hasConceptScore W2019912196C104317684 @default.
• W2019912196 hasConceptScore W2019912196C153911025 @default.
• W2019912196 hasConceptScore W2019912196C174832134 @default.
• W2019912196 hasConceptScore W2019912196C2778910516 @default.
• W2019912196 hasConceptScore W2019912196C2780026642 @default.
• W2019912196 hasConceptScore W2019912196C2910768159 @default.

• next