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- W2019912214 abstract "Hypoxia inducible factor 1 is regulated by the appearance of the HIF‐1α subunit. HIF‐1α is subjected to proteasomal destruction or enhanced protein translation, which requires the phosphatidylinositol 3‐kinase (PI3K)/Akt pathway. We investigated how PI3K/Akt and glycogen synthase kinase 3β (GSK3β) affect HIF‐1α in human RKO cells under prolonged periods of severe hypoxia/anoxia. 16‐ to 32‐h lasting incubations attenuated Akt activity and decreased HIF‐1α protein. This was reproduced by blocking PI3K with LY294002. GSK3β inhibition by indirubins circumvented the effect of hypoxia/anoxia or LY294002 on HIF‐1α. Ruling stability regulation of HIF‐1α protein and/or enhanced transcription of HIF‐1α mRNA via GSK3β inhibition out is suggestive for translational modulation of HIF‐1α under the influence of GSK3β." @default.
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- W2019912214 date "2004-12-21" @default.
- W2019912214 modified "2023-10-13" @default.
- W2019912214 title "Inhibition of GSK3β by indirubins restores HIF-1α accumulation under prolonged periods of hypoxia/anoxia" @default.
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- W2019912214 doi "https://doi.org/10.1016/j.febslet.2004.12.023" @default.
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