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• W2019913628 abstract "Metavanadate was evaluated for developmental toxicity in pregnant Swiss mice. Sodium metavanadate (NaVO3) was administered intraperitoneally on d 6–15 of gestation at doses of 0, 2, 4, or 8 mg/kg/d. On gestation d 18, all live fetuses were examined for external, visceral, and skeletal malformations and variations. Maternal toxicity was observed at 2, 4, and 8 mg/kg/d as evidenced by decreased weight gain during treatment. Increased resorptions and dead fetuses, increased percentage postimplantation loss, and reduced fetal body weight per litter were observed at 4 and 8 mg/kg/d. There were no significant increases in the type or incidence of external and skeletal anomalies, but a significant increase in the incidence of cleft palate was detected at 8 mg/kg/d. The lowest‐observed‐adverse‐effect level (LOAEL) for maternal toxicity was 2 mg NaVO3/kg/d, while 2 mg/kg/d was also the no‐observed‐adverse‐effect level (NOAEL) for significant developmental toxicity." @default.
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• W2019913628 date "1992-09-01" @default.
• W2019913628 modified "2023-10-09" @default.
• W2019913628 title "Embryotoxic and teratogenic effects of intraperitoneally administered metavanadate in mice" @default.
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• W2019913628 doi "https://doi.org/10.1080/15287399209531656" @default.
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