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• W2019914595 abstract "Ferritin plays a key role in determining the intracellular fate of iron and is highly regulated by the iron status of the cell. We have identified a cis-acting element in the transcribed but nontranslated 5' leader sequence of human ferritin heavy-chain mRNA. In transiently transfected murine fibroblasts, the presence of a 157-nucleotide region of the 5' leader sequence was found to be necessary for iron-dependent regulation of ferritin biosynthesis. Further, this 5' leader region is sufficient to transfer iron-mediated translational control to the expression of a heterologous gene product, chloramphenicol acetyltransferase." @default.
• W2019914595 created "2016-06-24" @default.
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• W2019914595 date "1987-10-01" @default.
• W2019914595 modified "2023-10-10" @default.
• W2019914595 title "A cis-acting element is necessary and sufficient for translational regulation of human ferritin expression in response to iron." @default.
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• W2019914595 doi "https://doi.org/10.1073/pnas.84.19.6730" @default.
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