FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019916478> ?p ?o ?g. }

• W2019916478 endingPage "1813" @default.
• W2019916478 startingPage "1806" @default.
• W2019916478 abstract "Endothelial dysfunction/loss is a key event in the development of vascular diseases, including native atherosclerosis (AS). Recent studies have shown that endothelial progenitor cells (EPCs) have the ability to repair endothelial cells that have been lost or damaged following AS. As a result, the therapy of transplanting EPCs is a promising option for the treatment of AS. However, the therapeutic effect on AS with only EPCs transplantation has not been satisfactory. The upregulation of those genes, which prevent the progress of AS in EPCs, is a novel therapeutic strategy for AS. Because it can reduce macrophage foam cell formation and protect endothelial cells from the oxidation of low-density lipoprotein (ox-LDL), paraoxonase-1 (PON1) gene is a candidate for gene therapy in AS. In this study, a recombinant adeno-associated virus (rAAV) vector carrying the human paraoxonase-1 (hPON1) gene (rAAV-PON1) was constructed, and endothelial progenitor cells (EPCs) transfected with rAAV-PON1 were transplanted into the atherosclerosis model of Sprague-Dawley rats (SD rats). The results of doppler ultrasound and histological analysis showed that the group transplanted with the hPON1 gene-transfected EPCs was superior to the group transplanted only with the EPCs and was also better than the group with hPON1 gene injection alone. The results indicated that rAAV-mediated hPON1 gene-transfected EPCs is a potentially valuable new tool in the treatment of atherosclerosis." @default.
• W2019916478 created "2016-06-24" @default.
• W2019916478 creator A5009165223 @default.
• W2019916478 creator A5026735983 @default.
• W2019916478 creator A5028641049 @default.
• W2019916478 creator A5030249691 @default.
• W2019916478 creator A5035028553 @default.
• W2019916478 creator A5070812231 @default.
• W2019916478 date "2010-01-01" @default.
• W2019916478 modified "2023-10-13" @default.
• W2019916478 title "Treatment of Atherosclerosis by Transplantation of Bone Endothelial Progenitor Cells Over-Expressed Paraoxonase-1 Gene by Recombinant Adeno-Associated Virus in Rat" @default.
• W2019916478 cites W1976578183 @default.
• W2019916478 cites W1987668354 @default.
• W2019916478 cites W1994953171 @default.
• W2019916478 cites W1999579644 @default.
• W2019916478 cites W2016596484 @default.
• W2019916478 cites W2025763389 @default.
• W2019916478 cites W2030069587 @default.
• W2019916478 cites W2031937052 @default.
• W2019916478 cites W2032591467 @default.
• W2019916478 cites W2034860964 @default.
• W2019916478 cites W2050562947 @default.
• W2019916478 cites W2053704719 @default.
• W2019916478 cites W2062249345 @default.
• W2019916478 cites W2063506869 @default.
• W2019916478 cites W2075620924 @default.
• W2019916478 cites W2081340075 @default.
• W2019916478 cites W2087736738 @default.
• W2019916478 cites W2088163556 @default.
• W2019916478 cites W2103790130 @default.
• W2019916478 cites W2105001034 @default.
• W2019916478 cites W2106669300 @default.
• W2019916478 cites W2109068464 @default.
• W2019916478 cites W2109773324 @default.
• W2019916478 cites W2120322365 @default.
• W2019916478 cites W2123627479 @default.
• W2019916478 cites W2125160350 @default.
• W2019916478 cites W2137123183 @default.
• W2019916478 cites W2137555841 @default.
• W2019916478 cites W2145805076 @default.
• W2019916478 cites W2147204790 @default.
• W2019916478 cites W2150545098 @default.
• W2019916478 cites W2153963475 @default.
• W2019916478 cites W2154168373 @default.
• W2019916478 cites W2155710930 @default.
• W2019916478 cites W2157760493 @default.
• W2019916478 cites W2164967692 @default.
• W2019916478 cites W2330503938 @default.
• W2019916478 cites W4248832562 @default.
• W2019916478 cites W4368104602 @default.
• W2019916478 cites W48439084 @default.
• W2019916478 doi "https://doi.org/10.1248/bpb.33.1806" @default.
• W2019916478 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21048304" @default.
• W2019916478 hasPublicationYear "2010" @default.
• W2019916478 type Work @default.
• W2019916478 sameAs 2019916478 @default.
• W2019916478 citedByCount "11" @default.
• W2019916478 countsByYear W20199164782012 @default.
• W2019916478 countsByYear W20199164782014 @default.
• W2019916478 countsByYear W20199164782016 @default.
• W2019916478 countsByYear W20199164782017 @default.
• W2019916478 countsByYear W20199164782018 @default.
• W2019916478 countsByYear W20199164782019 @default.
• W2019916478 countsByYear W20199164782020 @default.
• W2019916478 countsByYear W20199164782021 @default.
• W2019916478 countsByYear W20199164782023 @default.
• W2019916478 crossrefType "journal-article" @default.
• W2019916478 hasAuthorship W2019916478A5009165223 @default.
• W2019916478 hasAuthorship W2019916478A5026735983 @default.
• W2019916478 hasAuthorship W2019916478A5028641049 @default.
• W2019916478 hasAuthorship W2019916478A5030249691 @default.
• W2019916478 hasAuthorship W2019916478A5035028553 @default.
• W2019916478 hasAuthorship W2019916478A5070812231 @default.
• W2019916478 hasBestOaLocation W20199164781 @default.
• W2019916478 hasConcept C104317684 @default.
• W2019916478 hasConcept C111599444 @default.
• W2019916478 hasConcept C123012128 @default.
• W2019916478 hasConcept C126322002 @default.
• W2019916478 hasConcept C201750760 @default.
• W2019916478 hasConcept C202751555 @default.
• W2019916478 hasConcept C203014093 @default.
• W2019916478 hasConcept C2778107364 @default.
• W2019916478 hasConcept C2780152582 @default.
• W2019916478 hasConcept C28328180 @default.
• W2019916478 hasConcept C2911091166 @default.
• W2019916478 hasConcept C32470452 @default.
• W2019916478 hasConcept C40767141 @default.
• W2019916478 hasConcept C502942594 @default.
• W2019916478 hasConcept C54009773 @default.
• W2019916478 hasConcept C54355233 @default.
• W2019916478 hasConcept C71924100 @default.
• W2019916478 hasConcept C86803240 @default.
• W2019916478 hasConcept C92087593 @default.
• W2019916478 hasConcept C95444343 @default.
• W2019916478 hasConceptScore W2019916478C104317684 @default.
• W2019916478 hasConceptScore W2019916478C111599444 @default.
• W2019916478 hasConceptScore W2019916478C123012128 @default.
• W2019916478 hasConceptScore W2019916478C126322002 @default.

• next