Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019916503> ?p ?o ?g. }
Showing items 1 to 54 of
54
with 100 items per page.
- W2019916503 endingPage "ec238" @default.
- W2019916503 startingPage "ec238" @default.
- W2019916503 abstract "Cells and organisms have evolved quality control systems for sensing and responding to damaged and misfolded proteins, such as the induction of molecular chaperones through the heat shock transcription factor HSF-1 that occurs during the heat shock response (HSR). However, these systems fail to effectively control protein aggregation—and its deleterious consequences—in various disorders associated with chronic protein misfolding. Noting that the HSR in the nematode Caenorhabditis elegans is under neuronal control, Prahlad and Morimoto investigated the role of neuronal activity in the response to the chronic presence of abnormal proteins. Whereas C. elegans bearing loss-of-function mutations specifically affecting AFD thermosensory neurons and AIY interneurons (gcy-8 and ttx-3, respectively) show a decreased global HSR, these neuronal loss-of-function mutations led to decreased aggregation of a protein misfolding reporter (Q44::YFP, consisting of 44 glutamine residues fused to yellow fluorescent protein) expressed in intestinal cells. These mutations also decreased aggregation of Q35::YFP expressed in muscle cells and of a mutant aggregation-prone form of superoxide dismutase (SOD-1G93A) associated with amyotrophic lateral sclerosis, and attenuated a decrease in motility caused by muscle Q35, developmental defects associated with SOD-1G93A, and toxicity associated with misfolding of an isoform of paramyosin. Similarly, blocking the calcium-dependent neuronal secretion of dense core vesicles by deleting unc-31 decreased aggregation of Q44::YFP in intestinal cells and Q35::YFP in muscle. Knocking down HSF-1 restored protein aggregation in gcy-8 or unc-31 mutant worms, whereas combining gcy-8 with chronic expression of misfolded aggregation-prone proteins (but not either alone) elicited an HSF-1–dependent increase in the abundance of chaperone mRNA. Moreover, in contrast to their deficient response to acute heat shock, gcy-8 worms showed chaperone induction in response to chronic (repeated or prolonged) heat shock. The authors thus propose that neuronal regulation of chaperone production enables C. elegans to respond differently to acute or chronic stress." @default.
- W2019916503 created "2016-06-24" @default.
- W2019916503 creator A5077591824 @default.
- W2019916503 date "2011-08-30" @default.
- W2019916503 modified "2023-09-23" @default.
- W2019916503 title "A Different Response to Acute and Chronic Stress" @default.
- W2019916503 doi "https://doi.org/10.1126/scisignal.4188ec238" @default.
- W2019916503 hasPublicationYear "2011" @default.
- W2019916503 type Work @default.
- W2019916503 sameAs 2019916503 @default.
- W2019916503 citedByCount "0" @default.
- W2019916503 crossrefType "journal-article" @default.
- W2019916503 hasAuthorship W2019916503A5077591824 @default.
- W2019916503 hasConcept C104317684 @default.
- W2019916503 hasConcept C136238340 @default.
- W2019916503 hasConcept C143065580 @default.
- W2019916503 hasConcept C205260736 @default.
- W2019916503 hasConcept C2776104650 @default.
- W2019916503 hasConcept C2778944004 @default.
- W2019916503 hasConcept C55493867 @default.
- W2019916503 hasConcept C58207958 @default.
- W2019916503 hasConcept C86803240 @default.
- W2019916503 hasConcept C95444343 @default.
- W2019916503 hasConceptScore W2019916503C104317684 @default.
- W2019916503 hasConceptScore W2019916503C136238340 @default.
- W2019916503 hasConceptScore W2019916503C143065580 @default.
- W2019916503 hasConceptScore W2019916503C205260736 @default.
- W2019916503 hasConceptScore W2019916503C2776104650 @default.
- W2019916503 hasConceptScore W2019916503C2778944004 @default.
- W2019916503 hasConceptScore W2019916503C55493867 @default.
- W2019916503 hasConceptScore W2019916503C58207958 @default.
- W2019916503 hasConceptScore W2019916503C86803240 @default.
- W2019916503 hasConceptScore W2019916503C95444343 @default.
- W2019916503 hasIssue "188" @default.
- W2019916503 hasLocation W20199165031 @default.
- W2019916503 hasOpenAccess W2019916503 @default.
- W2019916503 hasPrimaryLocation W20199165031 @default.
- W2019916503 hasRelatedWork W1977537173 @default.
- W2019916503 hasRelatedWork W1994486588 @default.
- W2019916503 hasRelatedWork W2019916503 @default.
- W2019916503 hasRelatedWork W2128393290 @default.
- W2019916503 hasRelatedWork W2610256214 @default.
- W2019916503 hasRelatedWork W2962463215 @default.
- W2019916503 hasRelatedWork W2991037859 @default.
- W2019916503 hasRelatedWork W3147731158 @default.
- W2019916503 hasRelatedWork W3204674981 @default.
- W2019916503 hasRelatedWork W4283726950 @default.
- W2019916503 hasVolume "4" @default.
- W2019916503 isParatext "false" @default.
- W2019916503 isRetracted "false" @default.
- W2019916503 magId "2019916503" @default.
- W2019916503 workType "article" @default.