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• W2019916630 abstract "<i>Aim:</i> The first results from the French National Prader-Willi pediatric database in a cohort of 142 children aged 0.2–18.8 years are reported. This database gathers information about the endocrine dysfunctions traditionally described in Prader-Willi patients. <i>Methods:</i> Questionnaires were filled in by the patients’ practitioners. The coordination team of the reference center performed the statistical analysis. <i>Results:</i> Median BMI Z-score was +1.3 for a median age of 7.1 years, and 40% of the population were overweight or obese (International Obesity Task Force 2000 criteria). Growth hormone deficiency was present in 80% of patients and 86.7% were treated, with a height gain of +1 SD and a BMI reduction of –0.8 Z-score achieved in the first year of treatment. Hypogonadism was present in 49% of patients, and hypothyroidism in 24.4%. Glucose intolerance was found in 4% of patients, but no diabetes mellitus was detected in the 74 patients explored. <i>Conclusion:</i> Our report gives an overview of endocrine dysfunctions recorded in a large registry database of French children and adolescents with Prader-Willi syndrome. The database, which now encompasses six southern regions of France, will be further extended to the whole country and to adult patients." @default.
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• W2019916630 date "2010-01-01" @default.
• W2019916630 modified "2023-10-17" @default.
• W2019916630 title "Endocrine Disorders in Children with Prader-Willi Syndrome – Data from 142 Children of the French Database" @default.
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• W2019916630 doi "https://doi.org/10.1159/000313377" @default.
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