FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019917228> ?p ?o ?g. }

• W2019917228 endingPage "1027" @default.
• W2019917228 startingPage "1015" @default.
• W2019917228 abstract "The determinants of cancellous bone turnover and trabecular structure are not understood in normal bone or skeletal disease. Bone remodeling is initiated by osteoclastic resorption followed by osteoblastic formation of new bone. Receptor activator of nuclear factor kappaB ligand (RANKL) is a newly described regulator of osteoclast formation and function, the activity of which appears to be a balance between interaction with its receptor RANK and with an antagonist binding protein osteoprotegerin (OPG). Therefore, we have examined the relationship between the expression of RANKL, RANK, and OPG and indices of bone structure and turnover in human cancellous bone from the proximal femur. Bone samples were obtained from individuals with osteoarthritis (OA) at joint replacement surgery and from autopsy controls. Histomorphometric analysis of these samples showed that eroded surface (ES/BS) and osteoid surface (OS/BS) were positively associated in both control (p < 0.001) and OA (p < 0.02), indicating that the processes of bone resorption and bone formation remain coupled in OA, as they are in controls. RANKL, OPG, and RANK messenger RNA (mRNA) were abundant in human cancellous bone, with significant differences between control and OA individuals. In coplotting the molecular and histomorphometric data, strong associations were found between the ratio of RANKL/OPG mRNA and the indices of bone turnover (RANKL/OPG vs. ES/BS: r = 0.93, p < 0.001; RANKL/OPG vs. OS/BS: r = 0.80, p < 0.001). These relationships were not evident in trabecular bone from severe OA, suggesting that bone turnover may be regulated differently in this disease. We propose that the effective concentration of RANKL is related causally to bone turnover." @default.
• W2019917228 created "2016-06-24" @default.
• W2019917228 creator A5006336711 @default.
• W2019917228 creator A5017677081 @default.
• W2019917228 creator A5051520123 @default.
• W2019917228 creator A5065929346 @default.
• W2019917228 creator A5089104843 @default.
• W2019917228 date "2001-06-01" @default.
• W2019917228 modified "2023-10-07" @default.
• W2019917228 title "The Ratio of Messenger RNA Levels of Receptor Activator of Nuclear Factor κB Ligand to Osteoprotegerin Correlates with Bone Remodeling Indices in Normal Human Cancellous Bone but Not in Osteoarthritis" @default.
• W2019917228 cites W1650001464 @default.
• W2019917228 cites W1973256712 @default.
• W2019917228 cites W1980418071 @default.
• W2019917228 cites W1989159449 @default.
• W2019917228 cites W1994756823 @default.
• W2019917228 cites W2000647744 @default.
• W2019917228 cites W2001682983 @default.
• W2019917228 cites W2001952131 @default.
• W2019917228 cites W2002615436 @default.
• W2019917228 cites W2002727704 @default.
• W2019917228 cites W2003865675 @default.
• W2019917228 cites W2007487488 @default.
• W2019917228 cites W2020309083 @default.
• W2019917228 cites W2036368043 @default.
• W2019917228 cites W2048299560 @default.
• W2019917228 cites W2048621567 @default.
• W2019917228 cites W2060252166 @default.
• W2019917228 cites W2061472849 @default.
• W2019917228 cites W2063048904 @default.
• W2019917228 cites W2065308678 @default.
• W2019917228 cites W2068393364 @default.
• W2019917228 cites W2070335386 @default.
• W2019917228 cites W2078941715 @default.
• W2019917228 cites W2079317756 @default.
• W2019917228 cites W2093956992 @default.
• W2019917228 cites W2106766464 @default.
• W2019917228 cites W2107101733 @default.
• W2019917228 cites W2109608328 @default.
• W2019917228 cites W2120837197 @default.
• W2019917228 cites W2129651548 @default.
• W2019917228 cites W2139996507 @default.
• W2019917228 cites W2145026015 @default.
• W2019917228 doi "https://doi.org/10.1359/jbmr.2001.16.6.1015" @default.
• W2019917228 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11393778" @default.
• W2019917228 hasPublicationYear "2001" @default.
• W2019917228 type Work @default.
• W2019917228 sameAs 2019917228 @default.
• W2019917228 citedByCount "122" @default.
• W2019917228 countsByYear W20199172282012 @default.
• W2019917228 countsByYear W20199172282013 @default.
• W2019917228 countsByYear W20199172282014 @default.
• W2019917228 countsByYear W20199172282015 @default.
• W2019917228 countsByYear W20199172282016 @default.
• W2019917228 countsByYear W20199172282017 @default.
• W2019917228 countsByYear W20199172282018 @default.
• W2019917228 countsByYear W20199172282019 @default.
• W2019917228 countsByYear W20199172282020 @default.
• W2019917228 countsByYear W20199172282021 @default.
• W2019917228 countsByYear W20199172282022 @default.
• W2019917228 countsByYear W20199172282023 @default.
• W2019917228 crossrefType "journal-article" @default.
• W2019917228 hasAuthorship W2019917228A5006336711 @default.
• W2019917228 hasAuthorship W2019917228A5017677081 @default.
• W2019917228 hasAuthorship W2019917228A5051520123 @default.
• W2019917228 hasAuthorship W2019917228A5065929346 @default.
• W2019917228 hasAuthorship W2019917228A5089104843 @default.
• W2019917228 hasBestOaLocation W20199172281 @default.
• W2019917228 hasConcept C105702510 @default.
• W2019917228 hasConcept C126322002 @default.
• W2019917228 hasConcept C134018914 @default.
• W2019917228 hasConcept C142724271 @default.
• W2019917228 hasConcept C170033053 @default.
• W2019917228 hasConcept C170493617 @default.
• W2019917228 hasConcept C185592680 @default.
• W2019917228 hasConcept C204787440 @default.
• W2019917228 hasConcept C2776033226 @default.
• W2019917228 hasConcept C2776164576 @default.
• W2019917228 hasConcept C2776350087 @default.
• W2019917228 hasConcept C2779428903 @default.
• W2019917228 hasConcept C2780426850 @default.
• W2019917228 hasConcept C673006 @default.
• W2019917228 hasConcept C71924100 @default.
• W2019917228 hasConcept C88045685 @default.
• W2019917228 hasConceptScore W2019917228C105702510 @default.
• W2019917228 hasConceptScore W2019917228C126322002 @default.
• W2019917228 hasConceptScore W2019917228C134018914 @default.
• W2019917228 hasConceptScore W2019917228C142724271 @default.
• W2019917228 hasConceptScore W2019917228C170033053 @default.
• W2019917228 hasConceptScore W2019917228C170493617 @default.
• W2019917228 hasConceptScore W2019917228C185592680 @default.
• W2019917228 hasConceptScore W2019917228C204787440 @default.
• W2019917228 hasConceptScore W2019917228C2776033226 @default.
• W2019917228 hasConceptScore W2019917228C2776164576 @default.
• W2019917228 hasConceptScore W2019917228C2776350087 @default.
• W2019917228 hasConceptScore W2019917228C2779428903 @default.
• W2019917228 hasConceptScore W2019917228C2780426850 @default.
• W2019917228 hasConceptScore W2019917228C673006 @default.
• W2019917228 hasConceptScore W2019917228C71924100 @default.

• next