FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019917419> ?p ?o ?g. }

• W2019917419 endingPage "721" @default.
• W2019917419 startingPage "715" @default.
• W2019917419 abstract "Transient changes in the intracellular concentration of Ca 2+ provide a major signal for the regulation of many ion channels and enzymes in central neurones. In contrast, changes in extracellular Ca 2+ are thought to play little or no signaling role. However, concentrations of extracellular calcium in the central nervous system do change dramatically during intense physiological and pathological stimulation, and recent studies have identified a number of membrane proteins that can sense and respond to changes in extracellular Ca 2+ . These include the recently cloned Ca 2+ -sensing receptor, hemi-gap-junction channels, and a potential Ca 2+ -sensing cation channel. Lowering extracellular Ca 2+ strongly depolarizes and excites cultured hippocampal neurones. The excitation can be detected with decreases from physiological concentrations of as little as 100 µM. The depolarization results from activation of a nonselective cation current, which is sensitive to block by divalent and polyvalent cations. In outside-out patches, lowering Ca 2+ induces a single-channel current with a conductance of 36 pS. Activation of this cation channel, in response to decreases in extracellular Ca 2+ , likely plays a key role in a positive feedback system of excessive neuronal depolarization, which accompanies intense excitatory activity in the hippocampus.Key words: nonselective cation channel, calcium-sensing receptor, calcium-sensing channel, hemi-gap channels, extracellular calcium." @default.
• W2019917419 created "2016-06-24" @default.
• W2019917419 creator A5007598942 @default.
• W2019917419 creator A5018022392 @default.
• W2019917419 date "1999-10-10" @default.
• W2019917419 modified "2023-09-25" @default.
• W2019917419 title "Sensing of extracellular calcium by neurones" @default.
• W2019917419 cites W1607442726 @default.
• W2019917419 cites W1958525759 @default.
• W2019917419 cites W1964879917 @default.
• W2019917419 cites W1969912167 @default.
• W2019917419 cites W1971858361 @default.
• W2019917419 cites W1972460372 @default.
• W2019917419 cites W1979778632 @default.
• W2019917419 cites W1982272878 @default.
• W2019917419 cites W1982524452 @default.
• W2019917419 cites W1990154764 @default.
• W2019917419 cites W1998079157 @default.
• W2019917419 cites W2002372547 @default.
• W2019917419 cites W2005858187 @default.
• W2019917419 cites W2007998037 @default.
• W2019917419 cites W2009441758 @default.
• W2019917419 cites W2016517961 @default.
• W2019917419 cites W2016818162 @default.
• W2019917419 cites W2020433404 @default.
• W2019917419 cites W2022834612 @default.
• W2019917419 cites W2026193511 @default.
• W2019917419 cites W2026727419 @default.
• W2019917419 cites W2027625146 @default.
• W2019917419 cites W2029083259 @default.
• W2019917419 cites W2029810321 @default.
• W2019917419 cites W2031085390 @default.
• W2019917419 cites W2033048098 @default.
• W2019917419 cites W2034041490 @default.
• W2019917419 cites W2035750459 @default.
• W2019917419 cites W2036823824 @default.
• W2019917419 cites W2036976619 @default.
• W2019917419 cites W2045573157 @default.
• W2019917419 cites W2048152427 @default.
• W2019917419 cites W2048181576 @default.
• W2019917419 cites W2052196005 @default.
• W2019917419 cites W2053521526 @default.
• W2019917419 cites W2061160877 @default.
• W2019917419 cites W2062505059 @default.
• W2019917419 cites W2065390805 @default.
• W2019917419 cites W2066696082 @default.
• W2019917419 cites W2077135733 @default.
• W2019917419 cites W2078603061 @default.
• W2019917419 cites W2080494871 @default.
• W2019917419 cites W2088323064 @default.
• W2019917419 cites W2089414941 @default.
• W2019917419 cites W2100976024 @default.
• W2019917419 cites W2105952145 @default.
• W2019917419 cites W2122000164 @default.
• W2019917419 cites W2143502290 @default.
• W2019917419 cites W2143878967 @default.
• W2019917419 cites W2148381643 @default.
• W2019917419 cites W2166779237 @default.
• W2019917419 cites W2170271247 @default.
• W2019917419 cites W2324718767 @default.
• W2019917419 cites W2441717400 @default.
• W2019917419 cites W2471508020 @default.
• W2019917419 doi "https://doi.org/10.1139/y99-077" @default.
• W2019917419 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10566949" @default.
• W2019917419 hasPublicationYear "1999" @default.
• W2019917419 type Work @default.
• W2019917419 sameAs 2019917419 @default.
• W2019917419 citedByCount "35" @default.
• W2019917419 countsByYear W20199174192012 @default.
• W2019917419 countsByYear W20199174192013 @default.
• W2019917419 countsByYear W20199174192014 @default.
• W2019917419 countsByYear W20199174192015 @default.
• W2019917419 countsByYear W20199174192016 @default.
• W2019917419 crossrefType "journal-article" @default.
• W2019917419 hasAuthorship W2019917419A5007598942 @default.
• W2019917419 hasAuthorship W2019917419A5018022392 @default.
• W2019917419 hasConcept C112592302 @default.
• W2019917419 hasConcept C12554922 @default.
• W2019917419 hasConcept C170493617 @default.
• W2019917419 hasConcept C178790620 @default.
• W2019917419 hasConcept C181911157 @default.
• W2019917419 hasConcept C185592680 @default.
• W2019917419 hasConcept C18699975 @default.
• W2019917419 hasConcept C201571599 @default.
• W2019917419 hasConcept C28406088 @default.
• W2019917419 hasConcept C30979828 @default.
• W2019917419 hasConcept C4141045 @default.
• W2019917419 hasConcept C50254741 @default.
• W2019917419 hasConcept C519063684 @default.
• W2019917419 hasConcept C55493867 @default.
• W2019917419 hasConcept C74884574 @default.
• W2019917419 hasConcept C79879829 @default.
• W2019917419 hasConcept C86803240 @default.
• W2019917419 hasConceptScore W2019917419C112592302 @default.
• W2019917419 hasConceptScore W2019917419C12554922 @default.
• W2019917419 hasConceptScore W2019917419C170493617 @default.
• W2019917419 hasConceptScore W2019917419C178790620 @default.
• W2019917419 hasConceptScore W2019917419C181911157 @default.

• next