FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019918242> ?p ?o ?g. }

• W2019918242 endingPage "315" @default.
• W2019918242 startingPage "306" @default.
• W2019918242 abstract "During pulmonary development, there is a burst in elastin synthesis by interstitial fibroblasts coincident with the period of alveolar septal elongation. Little is known about the regulation of elastin synthesis by these cells, although several endocrine and paracrine factors influence lung fibroblast elastin production. Because alveolar septal elongation is accompanied by a decrease in capillary endothelial cell mitosis, we have hypothesized that a reduction in basic fibroblast growth factor (bFGF), an endothelial cell mitogen, may occur concomitantly with an increase in elastin synthesis. This temporal relationship suggests that bFGF may influence elastin production by interstitial fibroblasts. Therefore, we have examined the effects of bFGF on elastin production by postconfluent, serum-free cultures of lipid interstitial fibroblasts (LF). Elastin production was quantitated by analyzing the incorporation of 3H-valine into the soluble elastin precursor tropoelastin (TE). Exogenous bFGF decreased the quantity of newly synthesized TE in the culture media and cell layers of LF. The level of newly synthesized TE in the media was decreased to 36% and 48% of the unexposed control when LF were exposed for 48 h to 10 or 75 ng/ml bFGF, respectively. Northern analysis demonstrated that the decrease in TE was accompanied by a similar decrease in elastin mRNA. Transient transfection experiments using an elastin promoter/CAT gene construct demonstrated that bFGF exposure decreased elastin promoter activity. These results suggest that bFGF decreases elastin transcription. Exposure to an anti-bFGF antibody neutralized endogenous bFGF and increased soluble elastin production by LF. Our studies indicate that exogenous and endogenous bFGF can suppress elastin production by LF. A similar effect may occur in the intact lung during development or chronic inflammation." @default.
• W2019918242 created "2016-06-24" @default.
• W2019918242 creator A5041672482 @default.
• W2019918242 creator A5046833507 @default.
• W2019918242 date "1994-03-01" @default.
• W2019918242 modified "2023-09-25" @default.
• W2019918242 title "Basic fibroblast growth factor decreases elastin production by neonatal rat lung fibroblasts." @default.
• W2019918242 cites W1510586846 @default.
• W2019918242 cites W1517116499 @default.
• W2019918242 cites W1802322664 @default.
• W2019918242 cites W1854803455 @default.
• W2019918242 cites W1963681676 @default.
• W2019918242 cites W1968356075 @default.
• W2019918242 cites W1972795930 @default.
• W2019918242 cites W1974873948 @default.
• W2019918242 cites W1983239340 @default.
• W2019918242 cites W1986816160 @default.
• W2019918242 cites W1990205754 @default.
• W2019918242 cites W2003025783 @default.
• W2019918242 cites W2015127183 @default.
• W2019918242 cites W2042598773 @default.
• W2019918242 cites W2048216957 @default.
• W2019918242 cites W2048595604 @default.
• W2019918242 cites W2049042095 @default.
• W2019918242 cites W2055114143 @default.
• W2019918242 cites W2057048199 @default.
• W2019918242 cites W2062043596 @default.
• W2019918242 cites W2077896437 @default.
• W2019918242 cites W2082460645 @default.
• W2019918242 cites W2144712422 @default.
• W2019918242 cites W2155383324 @default.
• W2019918242 cites W2162740250 @default.
• W2019918242 cites W2163170931 @default.
• W2019918242 cites W2163424852 @default.
• W2019918242 cites W2171597870 @default.
• W2019918242 cites W2394621202 @default.
• W2019918242 cites W2407087799 @default.
• W2019918242 cites W2419705904 @default.
• W2019918242 cites W2797295276 @default.
• W2019918242 cites W7280909 @default.
• W2019918242 doi "https://doi.org/10.1165/ajrcmb.10.3.8117449" @default.
• W2019918242 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8117449" @default.
• W2019918242 hasPublicationYear "1994" @default.
• W2019918242 type Work @default.
• W2019918242 sameAs 2019918242 @default.
• W2019918242 citedByCount "50" @default.
• W2019918242 countsByYear W20199182422012 @default.
• W2019918242 countsByYear W20199182422014 @default.
• W2019918242 countsByYear W20199182422015 @default.
• W2019918242 countsByYear W20199182422016 @default.
• W2019918242 countsByYear W20199182422017 @default.
• W2019918242 countsByYear W20199182422019 @default.
• W2019918242 countsByYear W20199182422023 @default.
• W2019918242 crossrefType "journal-article" @default.
• W2019918242 hasAuthorship W2019918242A5041672482 @default.
• W2019918242 hasAuthorship W2019918242A5046833507 @default.
• W2019918242 hasConcept C126322002 @default.
• W2019918242 hasConcept C134018914 @default.
• W2019918242 hasConcept C170493617 @default.
• W2019918242 hasConcept C185592680 @default.
• W2019918242 hasConcept C202751555 @default.
• W2019918242 hasConcept C2775960820 @default.
• W2019918242 hasConcept C2777587049 @default.
• W2019918242 hasConcept C2779869378 @default.
• W2019918242 hasConcept C2780299668 @default.
• W2019918242 hasConcept C2780381497 @default.
• W2019918242 hasConcept C54355233 @default.
• W2019918242 hasConcept C55493867 @default.
• W2019918242 hasConcept C71924100 @default.
• W2019918242 hasConcept C7876069 @default.
• W2019918242 hasConcept C86803240 @default.
• W2019918242 hasConcept C95444343 @default.
• W2019918242 hasConceptScore W2019918242C126322002 @default.
• W2019918242 hasConceptScore W2019918242C134018914 @default.
• W2019918242 hasConceptScore W2019918242C170493617 @default.
• W2019918242 hasConceptScore W2019918242C185592680 @default.
• W2019918242 hasConceptScore W2019918242C202751555 @default.
• W2019918242 hasConceptScore W2019918242C2775960820 @default.
• W2019918242 hasConceptScore W2019918242C2777587049 @default.
• W2019918242 hasConceptScore W2019918242C2779869378 @default.
• W2019918242 hasConceptScore W2019918242C2780299668 @default.
• W2019918242 hasConceptScore W2019918242C2780381497 @default.
• W2019918242 hasConceptScore W2019918242C54355233 @default.
• W2019918242 hasConceptScore W2019918242C55493867 @default.
• W2019918242 hasConceptScore W2019918242C71924100 @default.
• W2019918242 hasConceptScore W2019918242C7876069 @default.
• W2019918242 hasConceptScore W2019918242C86803240 @default.
• W2019918242 hasConceptScore W2019918242C95444343 @default.
• W2019918242 hasIssue "3" @default.
• W2019918242 hasLocation W20199182421 @default.
• W2019918242 hasLocation W20199182422 @default.
• W2019918242 hasOpenAccess W2019918242 @default.
• W2019918242 hasPrimaryLocation W20199182421 @default.
• W2019918242 hasRelatedWork W1968384520 @default.
• W2019918242 hasRelatedWork W1986311309 @default.
• W2019918242 hasRelatedWork W1994287489 @default.
• W2019918242 hasRelatedWork W2032293082 @default.
• W2019918242 hasRelatedWork W2060463603 @default.

• next