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• W2019918735 abstract "The molecular cloning of two ligand-gated ion channels present in the primary afferent nociceptor terminal, i.e., the acid sensing ion channel ASIC and the capsaicin receptor VR1, was recently completed. ASICs are cationic channels rather selective for Na+ that are directly activated by a drop in the extracellular pH. They belong to the superfamily of amiloride-sensitive Na+ channels. They are composed of several homologous subunits, some of them being also present in the central nervous system, that can assemble in homo- or heteromultimers. A particular combination in the sensory neurons (ASIC2b and ASIC3) displays properties very close to that of the native channel involved in the perception of the non-adaptive pain associated with tissue acidosis. VR1 is a non-selective cationic channel that displays a high selectivity for Ca2+ and possess a structure different from that of ASIC but similar to that of store-operated channels (SOC). VR1 is specifically expressed in sensory neurons and is directly activated by vanilloid compounds like capsaicin. VR1 is also activated by noxious heat. The threshold for heat-evoked response is lowered by a decrease in the extracellular pH and VR1 is activated at normal physiological temperatures in the presence of low pH. The availability of these novel molecular probes will be important to study the pain mechanisms associated with these receptors and to develop new analgesic drugs that can modulate their activity." @default.
• W2019918735 created "2016-06-24" @default.
• W2019918735 creator A5006645417 @default.
• W2019918735 date "1999-09-01" @default.
• W2019918735 modified "2023-10-16" @default.
• W2019918735 title "Les récepteurs des protons et de la capsaïcine: Contribution à la physiologie et la physiopathologie de la douleur" @default.
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• W2019918735 doi "https://doi.org/10.1007/bf03008489" @default.
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